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The buffer capacity of the pancreatic juice

  • M. Tischer Hoerner
Experimental Physiology
  • 47 Downloads

Summary

An investigation was conducted on the properties of the pancreatic juice collected from pancreatic fistulas every half hour during fasting and after the ingestion of protein, carbohydrate, and fat test meals. A continuous secretion of pancreatic juice was noted at all times, provided there was no infection or leakage present. Protein diets stimulated a greater flow of secretion than any of the other test meals used. The amount of secretion depended largely on the size of the animal and the kind and quantity of food ingested. The buffering capacity of the pancreatic juice reached its maximum one to three hours after the ingestion of food and gradually diminished as the acidity in the duodenum decreased. The secretion was always alkaline and even possessed slight buffering power during fasting. When the buffering capacity was highest, 1 c.c. of pancreatic juice was capable of practically neutralizing an equal quantity of tenth-normal hydrochloric acid.

Keywords

Peptic Ulcer Pancreatic Duct Secretin Pancreatic Fistula Pancreatic Juice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Anrep, G. V., Lush, Joan L. and Palmer, M. Grace: Observations on pancreatic secretion.Jour. Physiol., 59:434–442 (Mar. 31) 1925.Google Scholar
  2. 2.
    Ball, E. G.: The composition of pancreatic juice and blood serum as influenced by the injection of acid and base.Jour. Biol. Chem., 86:433–448 (Apr.) 1930.Google Scholar
  3. 3.
    Ball, E. G.: The composition of pancreatic juice and blood serum as influenced by the injection of inorganic salts.Jour. Biol. Chem., 86:449–462 (Apr.) 1930.Google Scholar
  4. 4.
    Bayliss, W. M., and Starling, E. H.: On the uniformity of the pancreatic mechanism in vertebrata.Jour. Physiol., 29:174–180 (Mar. 16) 1903.Google Scholar
  5. 5.
    Carnot, P. and Gruzewska, Z.: Variations de concentration ionique de la bile et du suc pancréatique pendant la sécrétion acide du suc gastrique.Compt.-rend. Soc. de Biol., 93:240–242 (July 3) 1925.Google Scholar
  6. 6.
    Czubalski, F.: L’influence de l’alimentation sur la concentration en ions hydrogène (pH) du sac pancréatique.Compt.-rend. Soc. de Biol., 97:964–965 (Oct. 13) 1927.Google Scholar
  7. 7.
    Dubois, C. and Polonovski, Michel: Sur la concentration en ions hydrogene du suc pancréatique.Compt.-rend. Soc. de Biol., 93:632–633 (Aug. 14) 1925.Google Scholar
  8. 8.
    Elman, R. and McCaughan, J. M.: On the collection of entire external secretion of pancreas under sterile conditions and total effect of total loss of pancreatic juice.Jour. Exper. Med., 45:561–570 (Mar.) 1927.CrossRefGoogle Scholar
  9. 9.
    Gamble, J. L. and McIver, M. A.: Acid-base composition of pancreatic juice and bile.Jour. Exper. Med., 48:849–857 (Dec.) 1928.CrossRefGoogle Scholar
  10. 10.
    Johnston, C. G. and Ball, E. G.: Variations in inorganic constituents of the pancreatic juice during constant drainage of the pancreatic ducts.Jour. Biol. Chem., 86:643–653 (Apr.) 1930.Google Scholar
  11. 11.
    Jones, K. K.: Comparison of buffer value of bile and pancreatic juice secreted simultaneously.Proc. Soc. Exper. Biol. and Med., 28:567–568 (Mar.) 1931.Google Scholar
  12. 12.
    Mellanby, J.: The secretion of pancreatic juice.Jour. Physiol., 61:419–435 (June 22) 1926.Google Scholar
  13. 13.
    Popow, N. A., and Kudrjawzew, A. A.: Zur Lehre der Anpassungsfähigeit der Arbeit der Bauchspeicheldrüse and die Eigenschaften des Reizmittels. Der Einfluss des Gehalts an Säure in der in das Duodenum eingeführton Flüssigkeit auf pH des Bauchspeichels.Arch. f. d. ges. Physiol., 224:66–68, 1930.CrossRefGoogle Scholar
  14. 14.
    Zucker, T. F., Newburger, P. G. and Berg, B. N.: Chemical differentiation of nervous and hormonal panereatic secretion.Proc. Soc. Exper. Bicl. and Med., 30:166–167 (Nov.) 1932.Google Scholar

Copyright information

© Springer-Verlag 1935

Authors and Affiliations

  • M. Tischer Hoerner
    • 1
  1. 1.The Mayo FoundationRochester

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