The mechanism of the delay in gastric emptying time caused by anoxemia
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1. Studies on 23 additional dogs have entirely confirmed our previous reports showing that anoxemia causes a delay in gastric evacuation.
2. Removing, replacing or supplementing the pylorus prevents the delay caused by the less severe grades of anoxemia. This indicates that the delay resulting from mild anoxemia is due to pylorospasm. The more severe grades of anoxemia cause additional delay probably by directly depressing the motility of the stomach.
3. The pylorospasm is on a vagospastic basis since it disappears when the vagus fibers to the pylorus are cut without disturbing those to the stomach. Atropine cannot be used for this demonstration because it simultaneously depresses the motility of the stomach.
4. After removal or denervation of the pylorus mild anoxemia may cause faster evacuation because the vagospastic effect on gastric motility now becomes manifest. However, the postoperative normal emptying time is not shorter than the normal (760 mm.).
5. We conclude that the delay in gastric emptying time during anoxemia is at first,i. e., until a critical threshold is reached, upon a vagospastic pylorospastic basis. After this threshold is passed additional delay is caused by a loss in gastric motility.
KeywordsAtropine Vagus Stimulation Cent Oxygen Gastric Motility Severe Grade
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