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Conditioning of striatal dopamine metabolism with methadone, morphine or bulbocapnine as an unconditioned stimulus

  • Jorge Pérez-Cruet
Article
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Abstract

Psychotropic drugs such as methadone, morphine and bulbocapnine produce increments in dopamine metabolism as an unconditioned reflex. When a buzzer noise is used as a conditioned stimulus (CS) with these drugs as unconditioned stimuli, the buzzer CS acquires the properties of the drugs in increasing dopamine metabolism. These results suggest that the brain, like other visceral organs, can be conditioned in terms of neurotransmitter release or metabolism.

Keywords

Morphine Basal Ganglion Conditioned Stim Unconditioned Stimulus Conditioning Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Collins, K. H. and Tatum, A. L.: A conditioned salivary reflex established by chronic morphine poisoning.Am. J. Physiol. 74:14, 1925.Google Scholar
  2. Costa, E., Spano, P. F., Groppetti, A., Algeri, S., and Neff, N. H.: Simultaneous determinations of trytophan, tyrosine, catecholamines and serotonin specific activity in rat brain.Atti. Accad. Med. Lombardo 23:1100, 1968.Google Scholar
  3. Dolin, A. O.: Uslovno reflektorne Katalepticheskoe sostoianie (Conditioned reflex cataleptic condition).Zh vyssh. nerv. Deyat. Pavlova 1:485, 1951.Google Scholar
  4. Gantt, W. H., Reflexology, Schizokinesis and Autokinesis.Cond. Reflex. 1:57, 1966.Google Scholar
  5. Gessa, G. L., Di Chiara, G., Tagliamonte, A., and Pérez-Cruet, J.: Evidence that methadone inhibits dopamine receptors in brain, 5th Internat. Congress on Pharmacology. Free abstract communications, 1972; p. 77.Google Scholar
  6. Kobayashii, R. M., Palkovits, M., Jacobowitz, D. M., and Kopin, I. J.: Biochemical mapping of the noradrenergic projection from the locus coeruleus.Neurology 25:223, 1975.Google Scholar
  7. Laverty, R. and Taylor, K. M.: The fluorometric assay of catecholamines and related compounds. Improvements and extension of the hydroxyindole techniques.Anal. Biochem. 22:269, 1968.PubMedCrossRefGoogle Scholar
  8. Meisch, R. A. and Thompson, T.: Ethanol as a reinforcer: Effects of fixed ratio size and food deprivation.Psychopharmacologia 28:171, 1973.PubMedCrossRefGoogle Scholar
  9. Mello, N. K. and Mendelson, J. H.: Operant performance by rats for alcohol reinforcement: A comparison of alcohol-preferring and non-preferring animals.Quart. J. Stud. Alcohol 25:226, 1964.PubMedGoogle Scholar
  10. Pérez-Cruet, J. and Gantt, W. H.: Conditioned catalepsy to bulbocapnine: Cardiac, respiratory and motor components.Fed. Proc. 18:468, 1959.Google Scholar
  11. Pérez-Cruet, J. and Gantt, W. H.: Conditional reflex electrocardiogram to bulbocapnine: Conditioning of the T wave.Am. Heart J. 67:61, 1964.PubMedCrossRefGoogle Scholar
  12. Pérez-Cruet, J.: Cardio-respiratory components of conditional catalepsy to bulbocapnine. Neurophannacology, Excerpta Medica. Congress Series No. 129, Editor H. Brill, 1967; p. 912.Google Scholar
  13. Pérez-Cruet, J., Gessa, G. L., Tagliamonte, A., and Tagliamonte, P.: Evidence for a balance in basal ganglia between cholinergic and dopaminergic activity.Fed. Proc. 30:216, 1971.Google Scholar
  14. Pérez-Cruet, J., DiChiara, G., and Gessa, G. L.: Accelerated synthesis of dopamine in the rat brain after methadone. Experientia28:926, 1972.PubMedCrossRefGoogle Scholar
  15. Pérez-Cruet, J.: Conditioned reflex changes in dopamine metabolism induced by methadone as a conditioned reflex.In J. M. Singh and H. Lal (Eds.): Drug Addiction, 1974; p. 249.Google Scholar
  16. Pérez-Cruet, J., Thoa, N. B., and Ng, L. K. Y.: Acute effects of heroin and morphine on newly synthesized serotonin in rat brain.Life Sci. 17: 349, 1975.PubMedCrossRefGoogle Scholar
  17. Pert, C. B. and Snyder, S. H.: Opiate receptor: Demonstration in nervous tissue.Science 179:1011, 1973.PubMedCrossRefGoogle Scholar
  18. Pickens, R. and Harris, W. C.: Self-administration of d-amphetamine by rats.Psychopharmacologia 12:158, 1968.PubMedCrossRefGoogle Scholar
  19. Post, R. M., Kotin, J., Goodwin, F. K., and Gordon, E. K.: Psychomotor activity and cerebrospinal fluid amine metabolites in affective illnesses.Am. J. Psychiat. 130:67, 1973.PubMedGoogle Scholar
  20. Post, R. M. and Goodwin, F. K.: Simulated behavior states: An approach to specificity in psychobiological research.Biol. Psychiat. 7:237, 1973.PubMedGoogle Scholar
  21. Roffman, M., Reddy, C., and Lal, H.: Control of morphine-withdrawal hypothermia by conditioned stimuli.Psychopharmacologia 29:197, 1973.PubMedCrossRefGoogle Scholar
  22. Sasame, H., Pérez-Cruet, J., DiChiara, G., Tagliamonte, A., Tagliamonte, P., and Gessa, G. L.: Effect of methadone on dopamine metabolism in rat basal ganglia and its relation to catalepsy.Riv. Farmacol. Terap. 11:99, 1971.Google Scholar
  23. Sasame, H., Pérez-Cruet, J., DiChiara, G., Tagliamonte, A., Tagliamonte, P., and Gessa, G. L.: Evidence that methadone blocks dopamine receptors in the brain.J. Neurochem. 19:1953, 1972.PubMedCrossRefGoogle Scholar
  24. Schuster, C. R.: Psychological approaches to opiate dependence and selfadministration by laboratory animals.Fed. Proc. 29:2, 1970.Google Scholar
  25. Sedvall, G. C., Weise, V. K., and Kopin, I. J.: The rate of norephinephrine synthesis measuredin vivo during short intervals: Influence of adrenergic nerve impulse activity.J. Pharmacol. Exp. Ther. 159:274, 1968.PubMedGoogle Scholar
  26. Tagliamonte, A., Spano, P. F., Mazzucato, P., and Gessa, G. L.: Método par ’lestrazione e il dosaggio dell’ácido omovanílico nei tessuti.Boll. Soc. Ital. Biol. Sper. 44:420, 1967.Google Scholar
  27. Thompson, T. and Pickens, R.: Stimulus Properties of Drugs. New York, Appleton-Century-Crofts, 1971.Google Scholar
  28. Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain.Acta Physiol. Scand. (Suppl.),367:1, 1971.Google Scholar
  29. Wilder, A. and Pescor, F. T.: Classical conditioning of a morphine-abstinence phenomenon, reinforcement of opioid-drinking behavior and “relapse” in morphine-addicted rats.Psychopharmacologia (Berl.) 10:255–284, 1967.CrossRefGoogle Scholar
  30. Woods, J. H. and Schuster, C. R.: Reinforcing properties of morphine, cocaine and SPA as a function of unit dose.Internat. J. Addictions 3:231, 1968.Google Scholar

Copyright information

© Springer 1976

Authors and Affiliations

  • Jorge Pérez-Cruet
    • 1
  1. 1.The Department of Psychiatry, The Montreal General HospitalMcGill UniversityMontrealCanada

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