Live function in hepatic and extrahepatic diseases

1. The results of clinical experience with 326 cases
  • G. K. Wever
  • T. L. Althausen
  • G. R. Biskind
  • WM. J. Kerr
Clinical Medicine: Diseases Of Digestion


In our patients with acute hepatitis, as a group, the Rose Bengal test was positive in 94 per cent, and the modified glucose tolerance test in 93 per cent of cases. In chronic hepatitis, the dye excretion test was positive in 96 per cent, and the metabolic test was positive in 66 per cent of patients.

In patients with neoplasms of the liver, the Rose Bengal test was positive in 79 per cent and modified glucose tolerance in 60 per cent of cases.

A surprisingly large proportion of patients with extrahepatic diseases showed impairment by one or both tests. This applied especially to syphilis, hyperthyroidism, congestive heart failure, cholecystitis and diseases of the hematopoietic and nervous systems.

From a comparison of the two tests in 98 patients, we see that in diseases of the liver there was agreement between them in 72 per cent of cases. In the group of patients with neoplasms of the liver, agreement between the two tests was observed in 75 per cent of cases. When both tests were used in patients with extrahepatic diseases, consistent results were obtained in 66 per cent of cases. In the last group, the least degree of correlation is to be expected because the extrahepatic factors which influence carbohydrate metabolism on one hand, and the reticulo-endothelial system on the other, are apt to be more prominent than in the two groups with anatomical involvement of the liver where the hepatic factor is dominant.


Syphilis Rose Bengal Extrahepatic Disease Toxic Hepatitis Excretory Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Epstein, N. N.; Delprat, G. D., and Kerr, W. J.: The Rose Bengal Test for Liver Function.J. a. M. A., May 21, 1927, 88:1619.Google Scholar
  2. 2.
    Althausen, T. L.; Gunther, L.; Lagen, J. B., and Kerr, W. J.: Modification of the Dextrose Tolerance Test as an Index of Metabolic Activity of the Liver.Arch. Int. Med., 1930, 46:482.Google Scholar
  3. 3.
    Bernheim, A. R.: The Icterus Index.J. A. M. A., Jan. 26, 1924, 82:291.Google Scholar
  4. 4.
    Althausen, T. L.; Biskind, G. R., and Kerr, W. J.: The Rose Bengal Test of Hepatic Function.J. Lab. Exp. Med., 1933, 18:954.Google Scholar
  5. 5.
    Folin, O., and Wu, H.: A System of Blood Analysis: Simplified and Improved Method for Determination of Sugar.J. Biol. Chem., 1920, 41:367.Google Scholar
  6. 6.
    Jolliffe, N.: Liver Function in Catarrhal Jaundice.Am. J. Med. Sci., 1933, 186:640.CrossRefGoogle Scholar
  7. 7.
    Althausen, T. L., and Thoenes, E.: Influence on Carbohydrate Metabolism of Experimentally Induced Hepatic Changes. III Chloroform Poisoning.Arch. Int. Med., 1932, 50:257.Google Scholar
  8. 8.
    Biskind, G. R.; Epstein, N. N., andKerr, W. J.: Hepatic Complications in the Treatment of Syphilis.Ann. Int. Med., 1934, 7:966.Google Scholar
  9. 9.
    Althausen, T. L.: Functional Aspects of Regenerated Hepatic Tissue.Arch. Int. Med., 1931, 48:667.Google Scholar
  10. 10.
    Rao, M. V. R.: The Clinical Value of the Rose Bengal Test for the Determination of the Total Functional Capacity of the Liver.Indian J. Med. Res., 1932–33, 20:1009.Google Scholar
  11. 11.
    Mallory, F. B.: Cirrhosis of the Liver: Five Different Types of Lesions From Which it May Arise.Bull. J. Hopkins Hosp., 1911, 22:69.Google Scholar
  12. 12.
    Dieryck, J.: Recherches expérimentales sur les épreuves fonctionnelles du systeme réticulo-endothélial.Revue Belge des Sciences Medicales, 1929, 1:685.Google Scholar
  13. 13.
    Roe, J. H., and Schwartzman, A. S.: Galactose Tolerance as a Measure of Liver Function.Am. J. Med. Sci., 1933, 186:425.CrossRefGoogle Scholar
  14. 14.
    Youmans, J. B., and Warfield, S. M.: Liver Injury in Thyrotoxicosis as Evidenced by Decreased Functional Efficiency.Arch. Int. Med., 1926, 37:1.Google Scholar
  15. 15.
    Lichtman, S. S.: Liver Function in Hyperthyroidism.Arch. int. Med., 1932, 50:721.Google Scholar
  16. 16.
    Kerr, W. J., and Rusk, G. Y.: Acute Yellow Atrophy Associated with Hyperthyrodism.Med. Clin. North Am., 1922, 6:445.Google Scholar
  17. 17.
    Weller, C. V.: Hepatic Pathology in Exophthalmic Goiter. Ann. Int. Med., 1933, 7:543.Google Scholar
  18. 18.
    Beaver, D. C., and Pemberton, J. de J.: The Pathologic Anatomy of the Liver in Exophthalmic Goiter.Ann. Int. Med., 1933, 7:687.Google Scholar
  19. 19.
    Rowe, A. W.: Endocrine Studies: XXXV. The Association of Hepatic Dysfunction with Thyroid Failure.Endocrinology, 1933, 17:1.Google Scholar
  20. 20.
    Althausen, T. L., and Kerr, W. J.: Hemochromatosis.Endocrinology, 1927, 11:377 and 1933, 17:621.CrossRefGoogle Scholar
  21. 21.
    Bowen, B. D.; Vaughan, S. L., and Koenig, E. C.: Relation of Liver and Gall-bladder Diseases to Diabetes.Bull. Buffalo Gen. Hosp., 1928, 6:41.Google Scholar
  22. 22.
    Rich, A. R.: Pathogenesis of Forms of Jaundice.Bull. J. Hopkins Hosp., 1930, 47:338.Google Scholar
  23. 23.
    Robertson, W. E.; Swalm, W. A., and Konzelman, F. W.: Functional Capacity of the Liver.J. A. M. A., 1932, 99:2071.Google Scholar
  24. 24.
    Jolliffe, N.: Liver Function in Congestive Heart Failure.J. Clin. Invest., 1930, 8:419.PubMedCrossRefGoogle Scholar
  25. 25.
    Brooks, H.: Liver Disease Caused by Heart Defects.Med. Clin. N. Am., 1925, 9:311.Google Scholar
  26. 26.
    O’Leary, P. A.: Green, C. H., and Rowntree, L. G.: Diseases of the Liver. VIII. The Various Types of Syphilis of the Liver with Reference to Tests for Hepatic Function.Arch. Int. Med., 1929, 44:155.Google Scholar
  27. 27.
    Fernback, J.: Die Insulinempfindlichkeit bei Gehirnerkrankungen.Ztschr. f. klin. Med., 1932, 122:595.Google Scholar
  28. 28.
    Hess, L., and Goldstein, J.: Untersuchungen der Leberfunction im chronischen Stadium der Encephalitis epidemica.Med. klin., 1931, 27:1461.Google Scholar
  29. 29.
    Siedhoff, W.: Uber Störungen der Leberfurktion bei Erkrankungen des Mittelhirns.Ztschr. f. klin. Med., 1931, 118:383.Google Scholar
  30. 30.
    Richet, C.; Jacquelin, A., and Joly, F.: Manifestations hépatiques au cours d’états encephalo-méningés.Bull. et. mem. Soc. des Hop. de Paris, 1931, 47:1528.Google Scholar
  31. 31.
    Crandall, L. A.: Discussion in reference 23.Robertson, W. E.; Swalm, W. A., and Konzelman, F. W.:Google Scholar
  32. 32.
    Vogt, H.: Uber den Ablauf von Leberfunctionsstörungen bei Infektionskrankheiten.Ztsch. f. klin. Med., 1932, 122:33.Google Scholar
  33. 33.
    Van Creveld, S.: Function of the Liver in Scarlet Fever.Am. J. Dis. Child., 1932, 44:265.Google Scholar
  34. 34.
    Steidl, J., and Heise, F. H.: Studies of Liver Function in Advanced Pulmonary Tuberculosis.Am. J. Med. Sci., 1933, 186:631.CrossRefGoogle Scholar
  35. 35.
    Lereboullet: The Liver in Chronic Infections of Children. Abstract inJ. A. M. A., 1923, 80:284.Google Scholar
  36. 36.
    Thiébaut, F., and Diéryck, J.: L’Hépatite graisseuse tuberculeuse décelée par la galactosurie provoquée.Compt. rend. Soc. de Biol., 1931, 108:960.Google Scholar
  37. 37.
    Schleussing, H.: Nekrosen in Leber, Milz und Nebennieren bei nicht vereiterten Varizellen.Verhand. d. deut. path. Gesel., 1927, 22:288.Google Scholar
  38. 38.
    Kerr, W. J.; Delprat, G. D.; Epstein, N. N., and Duräevitz, M.: The Rose Bengal Test for Liver Function.J. A. M. A., 1925, 85:942.Google Scholar

Copyright information

© Springer-Verlag 1935

Authors and Affiliations

  • G. K. Wever
    • 1
  • T. L. Althausen
    • 1
  • G. R. Biskind
    • 1
  • WM. J. Kerr
    • 1
  1. 1.San Francisco

Personalised recommendations