Advertisement

Endocrine

, Volume 3, Issue 10, pp 751–754 | Cite as

8-OH-DPAT regulates the amplitude and the phase of LH surge in ovariectomized steroid-primed rats

  • M. Héry
  • A. M. François-Bellan
  • F. Héry
Papers

Abstract

Precise interactions between ovarian steroids and neurotransmitters are required for the secretion of phasic LH surge. Previous data suggested the existence of an interactive stimulatory effect of progesterone (P) and serotonin (5-HT) on LH release. In the present work the effects of 8-OH-DPAT, a selective 5-HT1A agonist, on phasic LH secretion were tested in ovariectomized rats implanted for 6 days with a pellet of 17 β estradiol (OVX-E2) and in OVX-E2 treated with progesterone (OVX-E2-P). Intraperitoneal injection of 8-OH-DPAT at 11.00 h in the morning of the expected LH surge had no effect on circadian plasma levels of LH in OVX-E2 rats, whereas it induced a phase advance and an increase in LH surge in OVX-E2-P rats. Administration of the antiprogestin RU 38486 in OVX-E2-P rat, totally abolished the combined effects of P and 8-OH-DPAT on phasic LH release. SDZ 216-525, a specific 5-HT1A antagonist administered 60 min before 8-OH-DPAT, inhibited the stimulatory effect of the 5-HT1A agonist on the amplitude of LH surge. The present data suggest that progesterone is required for the regulation of phasic LH release by 5-HT1A agonists and that under this hormonal condition the activation of 5-HT1A receptors induces a phase advance and an increase in LH surge.

Keywords

phasic LH release 8-OH-DPAT progesterone phase shift rat 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aguilar, E., Ranchal, A., Aguilar, R. & Pinilla, L. (1993).J. Neural. Transm.,94, 165–173.CrossRefGoogle Scholar
  2. Biegon, A. & McEwen, B.S. (1982).J. Neurosci.,2, 199–205.PubMedGoogle Scholar
  3. Chen, H.T., Sylvester, P.W., Ieri, T. & Meites, J. (1981).Endocrinology,108, 948–952.PubMedGoogle Scholar
  4. Cone, R.I., Davis, G.A. & Goy, R.W. (1981).Brain Res. Bull.,7, 639–644.PubMedCrossRefGoogle Scholar
  5. Dow, R.C., Williams, B.C., Bennie, J., Carroll, S. & Fink, G. (1994).Psychoneuroendoc,19, 395–399.CrossRefGoogle Scholar
  6. Edgar, D.M., Miller, J.D., Prosser, R.A., Dean, R.R. & Dement, W.C. (1993).J. Biol. Rhythms,8, 17–31.PubMedCrossRefGoogle Scholar
  7. Edgar, D.M., Seidel, W.F. & Dement, W.C. (1990).Sleep. Res.,19, 58–62.Google Scholar
  8. Frankfurt, M., Mendelson, S.D., McKittrick, C.R. & McEwen, B.S. (1993).Brain Res.,601, 349–352.PubMedCrossRefGoogle Scholar
  9. Franks, S., McElhone, J., Young, S.N., Kraulis, I. & Ruf, K.B. (1980).Endocrinology,107, 353–358.PubMedGoogle Scholar
  10. Hartter, D.E. & Ramirez, V.D. (1980).Endocrinology,107, 375–382.PubMedGoogle Scholar
  11. Hery, M., Becquet, D., Francois-Bellan, A.M., Deprez, P., Fache, M.P. & Hery, F. (1995).Neuroendocrinology,61, 11–18.PubMedCrossRefGoogle Scholar
  12. Hery, M., Faudon, M., Dusticier, G. & Hery, F. (1982).J. Endoc,94, 157–166.Google Scholar
  13. Hery, M., Laplante, E. & Kordon, C. (1978).Endocrinology,102, 1019–1025.PubMedGoogle Scholar
  14. Iyengar, S. & Rabii, J. (1983).Brain Res. Bull.,10, 339–343.PubMedCrossRefGoogle Scholar
  15. James, M.D., Hole, D.R. & Wilson, C.A. (1989).Neuroendocrinology,49, 561–569.PubMedCrossRefGoogle Scholar
  16. Johnson, J.H. & Sanders, K. (1987).Anat. Rec,218, 67A-68A.Google Scholar
  17. Johnson, M.D. & Crowley, W.R. (1986).Endocrinology,118, 1180–1186.PubMedCrossRefGoogle Scholar
  18. Ke, F.C. & Ramirez, V.D. (1987).Neuroendocrinology,45, 514–517.PubMedCrossRefGoogle Scholar
  19. Kiss, J. & Halasz, B. (1985).Neuroscience,14, 69–78.PubMedCrossRefGoogle Scholar
  20. Lauber, A.H., Romano, G.J. & Pfaff, D.W. (1991).J. Steroid Biochem. Mol. Biol.,40, 53–62.PubMedCrossRefGoogle Scholar
  21. Lenahan, S.E., Seibel, H. & Johnson, J.H. (1986).Neuroendocrinology,144, 89–94.CrossRefGoogle Scholar
  22. Lerman, J.A., Kaitin, K.I., Dement, W.C. & Peroutka, S.J. (1986).Neurosci. Lett.,72, 64–68.PubMedCrossRefGoogle Scholar
  23. Lovenberg, T.W., Baron, B.M., De Lecca, L., Miller, J.D., Prosser, R.A., Rea, M.A., Foye, P.E., Racke, M., Slone, A.L., Siegel, B.W., Danielson, P.E., Sutcliffe, F.G. & Erlander, M.G. (1993).Neuron.,11, 449–458.PubMedCrossRefGoogle Scholar
  24. Mendelson, S.D. & Gorzalka, B.B. (1986).Europ. J. Pharmacol.,132, 323–326.CrossRefGoogle Scholar
  25. Middlemiss, D.N. & Fozard, J.R. (1983).Eur. J. Pharmacol.,90, 151–153.PubMedCrossRefGoogle Scholar
  26. Prosser, R.A., Miller, J.D. & Heller, H.C. (1990).Brain Res.,534, 336–339.PubMedCrossRefGoogle Scholar
  27. Schoeffter, P., Fozard, J.R., Stoll, A., Siegl, H., Seiler, M.P. & Hoyer, D. (1993).Eur. J. Pharmacol. - Molecular Pharmacol. section,244, 251–257.CrossRefGoogle Scholar
  28. Sotelo, C, Cholley, B., El Mestikawi, S., Gozlan, H. & Hamon, M. (1990).Eur. J. Neurosci.,2, 1144–1154.PubMedCrossRefGoogle Scholar
  29. Tanaka, E., Baba, N., Toshida, K. & Suzuki, K. (1993).Life Sci.,52, 669–676.PubMedCrossRefGoogle Scholar
  30. Verge, D., Daval, G., Marcinkiewicz, M., Patey, A., El Mestikawi, S., Gozlan, H. & Hamon, M. (1986).J. Neurosci.,6, 3474–3482.PubMedGoogle Scholar
  31. Vitale, M.L., et Chiocchio, S.R. (1993).Endocrine Reviews,4, 480–493.CrossRefGoogle Scholar
  32. Walker, R.F. & Wilson, C.A. (1983).Neuroendocrinology,37, 200–205.PubMedCrossRefGoogle Scholar
  33. Wright, D.E. & Jennes, L. (1993).Neurosci. Lett.,163, 1–4.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • M. Héry
    • 1
  • A. M. François-Bellan
    • 1
  • F. Héry
    • 1
  1. 1.Laboratoire de Neuroendocrinologie ExpérimentalFaculté de Médecine Nord, Bd Pierre Dramard, Institut Jean RocheMarseille Cedex 20France

Personalised recommendations