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Preparation and characterization of nanosized hydroxyapatite particles in AOT inverse microemulsion

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Abstract

Nanosized particles of hydroxyapatite (HAP) were synthesized by reacting Ca (H2 PO4)2· H2 0 solution complex with equimolar Ca(OH)2 saturated solution in sodium bis (2-ethylhexyl) sulfosuccinate (AOT)/isooctane water-in-oil microemulsion. The formation of microemulsion strongly depended on water content w (w = [H2O]/[AOT] molar ratio) and concentration of surfactant and cosurfactant (1-octanol). By the variety of conductivity with w and the partial ternary phase diagram derived from a series of demarcation points, we set the basic component of microemulsions: [AOT] = 0. 1 M(mol/ dm3), [1-octanol] = 0.1 M and w = 3–9. Dynamic light scattering (DLS), UV-visible absorbance, TEM analysis and X-ray diffraction were used to characterize the microemulsion, formation of particles and resulting HAP particles. At low water content (w < 9), the water pool radius of the droplet in the Ca(H2 PO4)2 · H2O microemulsion lineally depended on w. The size of final HAP particles was strongly affected by water content w and reactant concentration. With increasing water content w from 3 to 9, the size of HAP particles increased from 10–20 nm to 40–50 nm at reactant concentration [Ca(H2 PO4) 2 · H2 0] = 12 × 10-3 mol/ dm3. The resulting HAP particles were poorly crystallized and spherical in morphology.

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Authors and Affiliations

  1. Biomedical Materials and Engineering Reseach Center, Wuhan University of Technology, 430070, Wuhan, China

    Ren Wei Ph D (Senior Engineer), Li Shi-pu, Wang You-fa, Cao Xian-ying & Chen Xiao-ming

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  1. Ren Wei Ph D
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  2. Li Shi-pu
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  3. Wang You-fa
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  4. Cao Xian-ying
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  5. Chen Xiao-ming
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Funded by “973” State Key Fundamental Research and Development (G1999064701)

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Ren, W., Li, Sp., Wang, Yf. et al. Preparation and characterization of nanosized hydroxyapatite particles in AOT inverse microemulsion. Journal of Wuhan University of Technology-Mater. Sci. Ed. 19, 24–29 (2004). https://doi.org/10.1007/BF03000161

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  • DOI: https://doi.org/10.1007/BF03000161

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