The American Journal of Digestive Diseases

, Volume 8, Issue 9, pp 329–333 | Cite as

The relation of nutrition to gastric function

III. The effect of vitamin B1 deficiency
  • Helen M. Dyer
  • Joseph H. Roe


Studies were made with rats of the effect of Vitamin B1 deficiency on gastric function. Following mecholyl stimulation, the volumes of gastric juice were recorded and the composition was investigated with respect to total acidity and free HCl. The experimental results indicate that acute or chronic B1 deficiencies in rats have no pathologic effect on the gastric secreting cells. Since a diminished response to gastric stimulation does not occur until the animals are moribund and the diminished response of moribund animals is promptly overcome by B1 therapy, it would appear that no serious damage to the secreting cells of the gastric mucosa occurs even with conditions of extreme deficiency.


Gastric Juice Gastric Secretion Thiamin Deficiency Vitamin Deficiency Deficient Animal 
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Copyright information

© Springer 1941

Authors and Affiliations

  • Helen M. Dyer
    • 1
  • Joseph H. Roe
    • 1
  1. 1.Department of Biochemistry, School of MedicineGeorge Washington UniversityWashington

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