Prothrombin and fibrinogen studies in chronic ulcerative colitis
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Twenty-one patients with chronic ulcerative colitis were studied to determine the prothrombin clotting time over periods up to twenty-one weeks.
Six patients (28.5%) had a constant hypopro-thrombinemia. Thirteen patients (61.9%) fluctuated between normal and elevated prothrombin clotting time and can be classified as having a borderline hypo-prothrombinemia. Two patients (9.5%) had repeated prothrombin clotting times within the normal range.
More than one prothrombin clotting time must be determined on the same patient with chronic ulcerative colitis since the prothrombin time for such individuals varies widely from week to week.
From the data presented it would appear that hypo-prothrombinemia may be more frequent than is supposed in patients with chronic ulcerative colitis.
Eleven patients with chronic ulcerative colitis were studied as to plasma fibrinogen content. Plasma of patients with chronic ulcerative colitis contains somewhat more fibrinogen than normal adults.
The only alteration in the blood clotting mechanism in chronic ulcerative colitis would appear to be a frequent occurrence of a low blood prothrombin level and this may explain some of the continued rectal bleeding that occurs in this disease.
KeywordsNormal Adult Chronic Ulcerative Colitis Plasma Fibrinogen Level Ative Colitis Oxalated Plasma
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