The American Journal of Digestive Diseases

, Volume 9, Issue 12, pp 419–422 | Cite as

Prothrombin and fibrinogen studies in chronic ulcerative colitis

  • Robert C. Page
  • Z. Bercovitz


Twenty-one patients with chronic ulcerative colitis were studied to determine the prothrombin clotting time over periods up to twenty-one weeks.

Six patients (28.5%) had a constant hypopro-thrombinemia. Thirteen patients (61.9%) fluctuated between normal and elevated prothrombin clotting time and can be classified as having a borderline hypo-prothrombinemia. Two patients (9.5%) had repeated prothrombin clotting times within the normal range.

More than one prothrombin clotting time must be determined on the same patient with chronic ulcerative colitis since the prothrombin time for such individuals varies widely from week to week.

From the data presented it would appear that hypo-prothrombinemia may be more frequent than is supposed in patients with chronic ulcerative colitis.

Eleven patients with chronic ulcerative colitis were studied as to plasma fibrinogen content. Plasma of patients with chronic ulcerative colitis contains somewhat more fibrinogen than normal adults.

The only alteration in the blood clotting mechanism in chronic ulcerative colitis would appear to be a frequent occurrence of a low blood prothrombin level and this may explain some of the continued rectal bleeding that occurs in this disease.


Normal Adult Chronic Ulcerative Colitis Plasma Fibrinogen Level Ative Colitis Oxalated Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mackie, T. T.: “Ulcerative Colitis. II. Deficiency States.”J. A. M. A., 104:175, 1935.Google Scholar
  2. 2.
    Mackie, T. T.: “Vitamin K Deficiency in the Absence of Jaundice.”New York State J. Med., 50:987, 1940.Google Scholar
  3. 3.
    Butt, H. R. and Snell, A. M.: “Vitamin K,” p. 96, W. B. Saunders Co., Philadelphia, 1941.Google Scholar
  4. 4.
    Hult, H.: “Om K-Avitaminosos.”Nord. med., 4:3627, 1939.Google Scholar
  5. 5.
    Stewart, J. D. and Rourke, G. M.: “Prothrombin and Vitamin K Therapy.”New England J. Med., 221:403, 1939.CrossRefGoogle Scholar
  6. 6.
    Quick, A. J.: “The Nature of the Bleeding in Jaundice.”J. A. M. A., 110:1658, 1938.Google Scholar
  7. 7.
    Fullerton, H. W.: “Estimation of Prothrombin; Simplified Method.”Lancet, 2:195, 1940.CrossRefGoogle Scholar
  8. 8.
    Page, R. C. and Russell, H. K.: “Prothrombin Estimation Using Russell Viper Venom.”J. Lab. and Clin. Med., 26:1366, 1941.Google Scholar
  9. 9.
    Page, R. C., de Beer, E. J. and Orr, M. L.: “Prothrombin Studies Using Russell Viper Venom. II. Relation of Clotting Time to Prothrombin Concentration in Human Plasma.”J. Lab. and Clin. Med., 27:197, 1941.Google Scholar
  10. 10.
    Shapiro, S., Sherwin, B., Redish, M. and Campbell, H. A.: “Prothrombin Estimation: A Procedure and Clinical Interpretations.”Proc. Soc. Exper. Biol. and Med., 50:85, 1942.Google Scholar
  11. 11.
    Howe, P. E.: “Determination of Protein in Blood — A Micro Method.”J. Biol. Chem., 49:109, 1921.Google Scholar
  12. 12.
    Wu, H.: “A New Colorimetric Method for the Determination of Plasma Protein.”J. Biol. Chem., 51:33, 1922.Google Scholar
  13. 13.
    Koch, S. C. and McKeekin, T. L.: “A New Direct Nesslerization Micro-Kjeldahl Method and a Modification of the Nessler-Folin Reagent for Ammonia.”J. Am. Chem. Soc., 46:2066, 1924.CrossRefGoogle Scholar
  14. 14.
    Foster, D. P. and Whipple, G. H.: “Blood Fibrin Studies.”Am. J. Physiol., 58:407, 1922.Google Scholar

Copyright information

© Springer-Verlag 1942

Authors and Affiliations

  • Robert C. Page
    • 1
  • Z. Bercovitz
    • 1
  1. 1.New York

Personalised recommendations