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Tegafur plus MMC or ACNU in the treatment of advanced gastric cancer-a pilot study

  • Clinical Observations
  • Published:
Chinese Journal of Cancer Research

Abstract

Twenty four cases of advanced gastric cancer were divided into two groups according to the general condition of the patients (PS 0–2 and 3–4), further subdivided into localized abdominal form, liver metastatic form, ascitic form and distant metastatic form. These patients were allocated randomly into Regimen A or B. Regimen A: Tegafur 600 mg daily and Mitomycin C (MMC) 5 mg/m2/1–2 weeks. Regimen B: Tegafur 600 mg daily and ACNU (Nimustine, water-soluble Nitrosourea) 60 mg/week for 2 weeks. After a course of ACNU, it was with drawn for 4 weeks and then resumed again. The response rate of Regimen A was 3/11 (27%), that of Regimen B was 3/13 (23%).

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Authors and Affiliations

  1. Shanghai Institute of Digestive Disease, China

    Zhang Darong, Xiao Shudong, Jiang Shaoji & Minoru Kurihara

  2. Department of Internal Medicine, Toyosu Hospital, Showa University, Tokyo, Japan

    Minoru Kurihara

Authors
  1. Zhang Darong
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  2. Xiao Shudong
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  3. Jiang Shaoji
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  4. Minoru Kurihara
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Zhang, D., Xiao, S., Jiang, S. et al. Tegafur plus MMC or ACNU in the treatment of advanced gastric cancer-a pilot study. Chin J Cancer Res 2, 60–63 (1990). https://doi.org/10.1007/BF02997566

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  • DOI: https://doi.org/10.1007/BF02997566

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