Tegafur plus MMC or ACNU in the treatment of advanced gastric cancer-a pilot study
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Twenty four cases of advanced gastric cancer were divided into two groups according to the general condition of the patients (PS 0–2 and 3–4), further subdivided into localized abdominal form, liver metastatic form, ascitic form and distant metastatic form. These patients were allocated randomly into Regimen A or B. Regimen A: Tegafur 600 mg daily and Mitomycin C (MMC) 5 mg/m2/1–2 weeks. Regimen B: Tegafur 600 mg daily and ACNU (Nimustine, water-soluble Nitrosourea) 60 mg/week for 2 weeks. After a course of ACNU, it was with drawn for 4 weeks and then resumed again. The response rate of Regimen A was 3/11 (27%), that of Regimen B was 3/13 (23%).
KeywordsGastric Cancer Mitomycin Advanced Gastric Cancer Tegafur Barium Meal
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