Immunological diagnosis of light chain disease analysis of 11 cases found in Fujian Province
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The present paper reports 11 cases of light chain disease (LCD) sequently found in several cities over Fujian province. Immunological classification of this group of LCD was as follows; six of the cases belonged to type λ, four of them were type κ, and another one was a double LCD. We found that LCD was common in Fujian only next to multiple myeloma (MM) of IgG class and accounted for 20%of the total 55 MM cases found in recent years.
It is well known that in most patients of LCD M protein or Bence Jones proteinemia (BJPemia) is not detectable by conventional electro- phoresis. Our studies show that by making serum protein along with urinary BJP electrophoresis on the same one gel plate the situation can be greatly improved It not only favours the recognition of small and faint band or bands of free light chain in serum, but also provides a repid and sensitive way, i. e. , immunofixation, to directly detect urinary light chain on the gel plate immediately after electrophresis has been run.
Key wordsMultiple myeloma Light chain disease Immunological diagnosis
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