A clinical study of the secretin test
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Thirty-three subjects were used for a clinical study of the effects of injecting purified secretin (Astra). Of these, eight were free of any gastro-intestinal diseases; the others had neoplasms of the pancreas, severe diabetes mellitus, chronic cholecystitis, chronic cholelithiasis, choledocholithiasis, or had been diagnosed as chronic pancreatitis.
The procedure of Ågren and Lagerlöf was modified by the use of a shorter period of collection. Both the analytical procedures and the calculation of the units for expressing enzymatic activity were also modified.
The results obtained for pancreatic secretion were similar to those reported by others: (a) a diminished secretion of the pancreas if the carcinoma was located in the head of the gland, but not when it was in other regions; (b) no marked association of disturbed pancreatic secretion and chronic diseases of the gall bladder.
Four out of the six cases of severe diabetes mellitus had distinctly low volumes of secretion plus low concentration and total output of bicarbonate, with some abnormalities in the enzymes.
One case with clinical evidence of chronic pancreatitis showed no evidence of disturbed pancreatic function by the secretin test.
The stimulating effect of the secretin on the liver proved valuable as a test for gall bladder function. The correlation between these results and the clinical findings was good.
KeywordsAmylase Chronic Pancreatitis Gall Bladder Secretin Pancreatic Secretion
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