Chinese Journal of Cancer Research

, Volume 3, Issue 4, pp 24–30 | Cite as

Dynamic parameter of membrane lipid in lung cancer cell lines, carcinogenesis cells and cancer cells isolated from patients with lung cancer

  • Qi Zirong 
  • Sun Ling 
  • Liu Jinwei 
Basic Investigation


With the aid of the Fluorescent lipophilic probe DPH (1, 6- diphenyl- 1, 3, 5- hexatriene ), the degree of microviscosity (η) and lipid fluidity (LFU) obtained from lung cancer lines and carcinogenesis cells induced by irradiation as well as the patients with lung cancer were quantitatively monitored by Fluorescence polarization. The results have shown a marked decreased in ti and a significant increase in LFU in various tumor cells as compared to normal cells. Sometime, the degree of fluidity in carcinogenesis cells induced by radiation and the patients with lung cancer have shown to be similar pattern. The possibility that these dynamic parameter may serve as a diagnostic tool for an early detection of lung cancer is discussed.

Key words

fluidity of membrane lipid DPH-labeled lung cancer Carcinogenesis cell 238Pu-α particle irraciation 


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Copyright information

© Chinese Journal of Cancer Research 1991

Authors and Affiliations

  • Qi Zirong 
    • 1
  • Sun Ling 
    • 1
  • Liu Jinwei 
    • 1
  1. 1.Department of Tuberculosis309 hospitalBeijing

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