Abstract
The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premycotic stage, 24 MF II infiltrative stage and 4 MF III — tumor stage), 2 nonepidermotropic cutaneous T cell lymphoma (NECTCL) and 9 CPL were investigated. In each case, 200 cells randomly selected were examined using a × 100 oil immersion lens. The mean number, standard deviation and standard error of the mean of AgNOR counts were as follows: MFI 1.17±0.09, SEM=0.01; MF II 1.17±0.01, SEM=0.01; MF III 3.55±0.87, SEM=0.43; NECTCL 4.5±0.28, SEM=0.199; CPL 1.17±0.1, SEM±0.03. The results revealed a highly significant difference between CTCL (MF III+NECTCL) and CPL (t=4.75,P<0.001), tumor stage (MF III) and pretumor stage (MFI, MF II) of mycosis fungoides (t=4.75,P<0.001). Thus. AgNOR count is valuable in differential diagnosis.
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Xu, L., Chen, H., Qiu, B. et al. Nucleolar organizer regions in cutaneous T cell lymphomas. Chin J Cancer Res 2, 58–61 (1990). https://doi.org/10.1007/BF02997234
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DOI: https://doi.org/10.1007/BF02997234