Chinese Journal of Cancer Research

, Volume 2, Issue 3, pp 39–42 | Cite as

A preliminary study on the relationship between murine IgE level and 3-methylcholanthrene induced fibrosarcoma

  • Zhang Ke 
  • Zheng Shanshan 
  • Wu Anran 
Basic Investigation


The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methylcholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgG1 had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgG1 could not. The data from this study did not show that IgE, IgG or IgG1 had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.


IgG1 Level Fibrosarcoma Tumor Incidence Tumor Growth Rate Histamine Level 
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Copyright information

© Chinese Journal of Cancer Research 1990

Authors and Affiliations

  • Zhang Ke 
    • 1
  • Zheng Shanshan 
    • 1
  • Wu Anran 
    • 1
  1. 1.Department of Immunology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences WHO Collaborating Center for Immunological ResearchBeijing

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