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Chinese Journal of Cancer Research

, Volume 2, Issue 3, pp 1–5 | Cite as

Carcinogenicity of fusarin C isolated fromFusarium moniliforme

  • Li Mingxin 
  • Jiang Yuanzhou 
  • Bjeldanes L F 
Basic Investigation

Abstract

Fusarium moniliforme, a fungus of established carcinogenic potential, is one of the most common fungal contaminants of maize, millet and other grains in Linxian County, China. Fusarin C, a major product ofF. moniliforme grown on corn in the laboratory, is mutagenic inSalmonella tester strains and in V79 cells. Fusarin C showed several characteristics of malignant transformation including the implantation of the rat esophageal epithelial cell line (RE — 525) in nude mice. The present work demonstrated that fusarin C can induce esophageal and forestomach carcinomas in DBA mice and Wistar rats, and thus the experimental results substantiated further the carcinogenicity of fusarin C.

Keywords

Esophageal Cancer Papilloma Glandular Stomach Metabolic Activation System Cancer Cell Nest 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chinese Journal of Cancer Research 1990

Authors and Affiliations

  • Li Mingxin 
    • 1
  • Jiang Yuanzhou 
    • 1
  • Bjeldanes L F 
    • 2
  1. 1.Cancer InstituteChinese Academy of Medical SciencesBeijing
  2. 2.Department of Nutritional SciencesUniversity of CaliforniaBerkeleyUSA

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