A Clinical Study of Local Acriflavin in Treatment of Rhinoscleroma

  • Abhay Gupta
  • Vineeta Gupta
  • S. R. Agarwal
  • A. K. Jain
Short communication


Rhinoscleroma is a chronic granulomatous disease which involves upper respiratory tract. We undertook this study to find out the antibacterial effect of local acriflavin on Klebsiella rhinoscleromatis, as well as the disease rhinoscleroma. Antibiotic effect of acriflavin was studied on one of the isolate of Klebsiella rhinoscleromatis using whatman No.1 filter paper disc soaked in 2% and 5% acriflavin solution and was found sensitive. A total of 26 cases diagnosed clinically and histopathologically were studied. These patients were treated using 1%, 2% and 5% acriflavin ointment. The cure was 33%, 67% and 100% respectively. Details of response to acriflavin therapy and its adverse effect will be discussed. It is concluded that acriflavin can be used as a good alternative to systemic therapy for rhinoscleroma. As it can be prepared and applied easily and is not a financial burden on already poor patient.

Key Words

Rhinoscleroma Therapy Acriflavin Scleroma 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Quevedo J (1949): Scleroma in Guatmela; a study of disease based on experience of 108 cases, JLO; 49: 789–809.Google Scholar
  2. 2.
    Chaturvedi V.N. (1981): Scleroma, Report of 6 cases Indian Medical Gazette; July, 115: 244–8Google Scholar
  3. 3.
    Toppozada HH, Mazloum H, Gamea A (1983): Complement fixation test in rhinoscleroma, JLO, Jan; 97 (1): 55–7CrossRefGoogle Scholar
  4. 4.
    Shaw HJ & Martin H (1961): Rhinoscleroma; A clinical perspective. J. Laryng, Dec; 75. 1011–1039.Google Scholar
  5. 5.
    Ssali (1975): Management of rhinoscleroma. J. Laryngol Otolar, Jan; 89 (1): 91–9Google Scholar
  6. 6.
    Shum TK, Whitekar CW, Meyer PR (1982): Clinical update on Rhinoscleroma. Laryngoscope, 92: 1149–1153PubMedCrossRefGoogle Scholar
  7. 7.
    Cone LA, Barton SM, Woodened D.R. (1987): Treatment of scleroma ceforanide. Arch Otolaryngol Head Neck Surg. Apr; 113 (4): 374–6PubMedGoogle Scholar
  8. 8.
    Shehata MP & Salama AM (1989): Clofazimin in the treatment of scleroma. JLO, Sep.; 103: 856–860CrossRefGoogle Scholar
  9. 9.
    Gamea AM (1988): Local Rifampicin in treatment of Rhinoscleroma. JLO: 1–2: 319–321Google Scholar
  10. 10.
    Gamea AM & Eltawai FA (1990): The effect of Rifampicin on Rhinoscleroma; an electron microscopic study, J. Laryngol Otology, Oct; 104 (10), 772–7Google Scholar
  11. 11.
    Shaer M, Ali M, Hashish M. (1981): Local acriflavin; a new therapy for rhinoscleroma. JLO; 95 (7): 701–6.CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 1999

Authors and Affiliations

  • Abhay Gupta
    • 1
  • Vineeta Gupta
    • 2
  • S. R. Agarwal
    • 3
  • A. K. Jain
    • 4
  1. 1.Dept., of E.N.T.G. R. Medical CollegeGwalior
  2. 2.Dept. of MicrobiologyPravara Rural Medical CollegeLoni
  3. 3.Dept. of OtorhinolarygologyG. R. Medical CollegeGwalior
  4. 4.Dept. of OtorhinolarygologyG. R. Medical CollegeGwalior

Personalised recommendations