Abstract
The production of 6APA by enzymatic hydrolysis of penicillin G can be integrated with the production of penicillin G. The penicillin G solutions obtained during the extraction from the fermented broth can be directly hydrolyzed to 6APA and phenyl acetic acid. The 6APA is then recovered while the phenyl acetic acid can also be recovered and recycled to the fermentation plant. Some of the results obtained by the research work performed by SNAM Progetti in their Microbiological Laboratories with the advice of Biochem Design are presented and analyzed. The economic potential of the integrated process is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dinelli, D. (1972) Process Biochem. 7: 9.
Batchelor, F. R., Chain, E. B., Hardy, T. L., Mansford, K. R. L., andRolinson, G. H. (1961) Proc. Roy. Soc. B154: 498.
Alicino, J. F. (1961) Anal. Chem. 33: 648.
Bomstein, J. (1965) Anal. Chem. 37: 576.
Balasingham, K., Warburton, D., Dunnill, P., andLilly, M. D. (1972) Biochem. Biophys. Acta 276: 250.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giacobbe, F., Iasonna, A. & Cecere, F. Novel developments for the production of 6APA in the penicillin g fermentation plant by using fiber-entrapped penicillin amidase. Journal of Solid-Phase Biochemistry 2, 195–202 (1977). https://doi.org/10.1007/BF02996741
Issue Date:
DOI: https://doi.org/10.1007/BF02996741