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Chinese Journal of Cancer Research

, Volume 4, Issue 4, pp 30–32 | Cite as

Researches on the anti-autologous tumor effects of human cancer-killing cells in nude mice

  • Zhang Binxue 
  • Tang Yao 
  • Zheng Jie 
  • Yin Cheng 
  • Wang Jieliang 
  • You Jiangfeng 
  • Fang Weigang 
  • Wu Bingquan 
  • Wang Xiuyun 
  • Gao Ronglian 
Basic Investigation
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Abstract

An investigation of human splenic LAK cells killing autologous tumor invivo has been performed in this study. Briefly, an ovary embryo carcinoma (OEC) removed surgically from patient was transplanted into nude mice (s. c.) and culturedin vitro, that would be used as targets. Lymphokine-activated killer (LAK) cells were generated from splenic lymphocytes of the OEC patient, who died two and half months after operation, by co- culture with recombinant human interleukin- 2 (rIL- 2) invitro. The results from Winn’ s test in nude mice suggested that these LAK cells could effectively inhibit the tumorigenicity of autologous tumorin vivo.

Key words

lymphokine-activated killer cells interleukin 2 nude mice 

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References

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Copyright information

© Chinese Journal of Cancer Research 1992

Authors and Affiliations

  • Zhang Binxue 
    • 1
  • Tang Yao 
    • 1
  • Zheng Jie 
    • 1
  • Yin Cheng 
    • 1
  • Wang Jieliang 
    • 1
  • You Jiangfeng 
    • 1
  • Fang Weigang 
    • 1
  • Wu Bingquan 
    • 1
  • Wang Xiuyun 
    • 2
  • Gao Ronglian 
    • 2
  1. 1.Department of PathologyBeijing Medical UniversityChina
  2. 2.Department of Gynecology and Obstetrics, the Third HospitalBeijing Medical UniversityChina

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