Researches on the anti-autologous tumor effects of human cancer-killing cells in nude mice
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An investigation of human splenic LAK cells killing autologous tumor invivo has been performed in this study. Briefly, an ovary embryo carcinoma (OEC) removed surgically from patient was transplanted into nude mice (s. c.) and culturedin vitro, that would be used as targets. Lymphokine-activated killer (LAK) cells were generated from splenic lymphocytes of the OEC patient, who died two and half months after operation, by co- culture with recombinant human interleukin- 2 (rIL- 2) invitro. The results from Winn’ s test in nude mice suggested that these LAK cells could effectively inhibit the tumorigenicity of autologous tumorin vivo.
Key wordslymphokine-activated killer cells interleukin 2 nude mice
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