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Sequential methotrexate and Radiotherapy in advanced laryngeal cancer

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Abstract

Surgery and/or Radiotherapy offers poor cure rate in the cases of advanced laryngeal cancer. Due to this fact a number of combined modality programmes have been piloted in which sequential chemotherapy and radiotherapy play an important role in the primary treatment plan. In present paper we have compared the results of sequential chemotherapy followed by external radiotherapy and radiotherapy alone. This study was carried out in 55 cases of advanced laryngeal carcinoma (Stage III and Stage IV). The chemotherapeutic agent used in this study was parenteral methotrexate. There was marked improvement in cure rate of advanced squamous cell carcinoma of larynx who received sequential methotrexate followed by external beam radiotherapy.

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References

  1. Friedman, M. and Daly, J.F. (1967), Combined irradiation and methotrexate treatment of squamous cell carcinoma of head and neck.Am. J. Roentg.,99: 289–301.

    PubMed  CAS  Google Scholar 

  2. Condit, P.T., Ridings, G.R. ; Coin, J.W. (1964), Tropical methotrexate and radiation in the treatment of patients with cancer.Cancer Research,24: 1524–1533.

    PubMed  CAS  Google Scholar 

  3. Kligerman, M.M., Hellman, S., Von Essen, C.F. (1966), Sequential chemotherapy and radiotherapy: Priliminary results of clinical trial with methotrexate in head and neck cancer.Radiology,86 : 247–250.

    PubMed  CAS  Google Scholar 

  4. Jesse, R.H., Villareal, R., Letaye, V. (1964), Intra-arterial infusion for head and neck cancer.Arch. Surg. 88: 618–627

    PubMed  CAS  Google Scholar 

  5. Sulliran, R.D., Miller, E. and Sikes, M.P. (1959), Antimetabolic combination cancer chemotherapy: effects of intra-arterial methotrexate intramuscular cetrovarum factor therapy in human cancer.Cancer,12 : 1248–1262.

    Article  Google Scholar 

  6. Papack, R.J., Jacobs, F.M., Foye, L.V. (1963), Systemic therapy with amithopterin in squamous carcinoma of head and neck region.Cancer Chemotherapy Rep. 34–47.

  7. Kramer, S. (1969), Use of methotrexate and radiation therapy for advanced cancer of head and neck.Frontiers, Radiation Ther. One. 4: 116–125.

    Google Scholar 

  8. Friedman, M., Felix, N., Narvacs, D.F. (1970), The treatment of squamous cell carcinoma of head and neck with combined methotrexate and radiation.Cancer,26: 711–721.

    Article  PubMed  CAS  Google Scholar 

  9. Pant, G.G., Sanyal, B. and Khanna, N.N. (1973), Sequential treatment of advanced oral carcinoma by methotrexate and radiotherapy.Indian J. Med. Res. 61: 848–855.

    PubMed  CAS  Google Scholar 

  10. Fletcher, H.G. ; Jesse, R.H. (1977), The place of radiation in the management of the primary lesion in the head and neck cancer.Cancer,39: 862–887.

    Article  PubMed  CAS  Google Scholar 

  11. Tarpley, J.L., Chretien, P.B. ; Alexcnder, J.C. (1975), High dose methotrexate as pre-operative adjuvant in treatment of epidermoid carcinoma of head and neck.Am. J. Surg. 130: 481–486.

    Article  PubMed  CAS  Google Scholar 

  12. Marciai et al., Quoted from Al. Sarraf, M. (1934), Chemotherapy strategies in squamous cell carcinoma of the head and neck.CRC Critical review in Oncology/Haematology,4: 323–354.

    Google Scholar 

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Authors and Affiliations

  1. Dept. of Radiotherapy & Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, 221 005, Varanasi

    Anupam Kumar Asthana (Lecturer) & Girish Chandra Pant (Professor & Head)

  2. Department of E.N.T., Institute of Medical Sciences, Banaras Hindu University, 221 005, Varanasi

    Rajeev Kumar Jain

  3. Hanuman Prasad Poddar Cancer Institute, Gorakhpur

    Om Prakash Singh (Senior Radiotherapist)

Authors
  1. Anupam Kumar Asthana
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  2. Rajeev Kumar Jain
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  3. Girish Chandra Pant
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  4. Om Prakash Singh
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Asthana, A.K., Jain, R.K., Pant, G.C. et al. Sequential methotrexate and Radiotherapy in advanced laryngeal cancer. Indian J Otolaryngol 41, 127–130 (1989). https://doi.org/10.1007/BF02994233

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