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Indian Journal of Otolaryngology

, Volume 41, Issue 3, pp 127–130 | Cite as

Sequential methotrexate and Radiotherapy in advanced laryngeal cancer

  • Anupam Kumar Asthana
  • Rajeev Kumar Jain
  • Girish Chandra Pant
  • Om Prakash Singh
Article
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Abstract

Surgery and/or Radiotherapy offers poor cure rate in the cases of advanced laryngeal cancer. Due to this fact a number of combined modality programmes have been piloted in which sequential chemotherapy and radiotherapy play an important role in the primary treatment plan. In present paper we have compared the results of sequential chemotherapy followed by external radiotherapy and radiotherapy alone. This study was carried out in 55 cases of advanced laryngeal carcinoma (Stage III and Stage IV). The chemotherapeutic agent used in this study was parenteral methotrexate. There was marked improvement in cure rate of advanced squamous cell carcinoma of larynx who received sequential methotrexate followed by external beam radiotherapy.

Keywords

Methotrexate Laryngeal Cancer Complete Response Rate Advanced Squamous Cell Carcinoma Sequential Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Association of Otolaryngologists of India 1989

Authors and Affiliations

  • Anupam Kumar Asthana
    • 1
  • Rajeev Kumar Jain
    • 2
  • Girish Chandra Pant
    • 1
  • Om Prakash Singh
    • 3
  1. 1.Dept. of Radiotherapy & Radiation Medicine, Institute of Medical SciencesBanaras Hindu UniversityVaranasi
  2. 2.Department of E.N.T., Institute of Medical SciencesBanaras Hindu UniversityVaranasi
  3. 3.Hanuman Prasad Poddar Cancer InstituteGorakhpur

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