Indian Journal of Otolaryngology

, Volume 41, Issue 3, pp 127–130 | Cite as

Sequential methotrexate and Radiotherapy in advanced laryngeal cancer

  • Anupam Kumar Asthana
  • Rajeev Kumar Jain
  • Girish Chandra Pant
  • Om Prakash Singh


Surgery and/or Radiotherapy offers poor cure rate in the cases of advanced laryngeal cancer. Due to this fact a number of combined modality programmes have been piloted in which sequential chemotherapy and radiotherapy play an important role in the primary treatment plan. In present paper we have compared the results of sequential chemotherapy followed by external radiotherapy and radiotherapy alone. This study was carried out in 55 cases of advanced laryngeal carcinoma (Stage III and Stage IV). The chemotherapeutic agent used in this study was parenteral methotrexate. There was marked improvement in cure rate of advanced squamous cell carcinoma of larynx who received sequential methotrexate followed by external beam radiotherapy.


Methotrexate Laryngeal Cancer Complete Response Rate Advanced Squamous Cell Carcinoma Sequential Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Friedman, M. and Daly, J.F. (1967), Combined irradiation and methotrexate treatment of squamous cell carcinoma of head and neck.Am. J. Roentg.,99: 289–301.PubMedGoogle Scholar
  2. 2.
    Condit, P.T., Ridings, G.R. ; Coin, J.W. (1964), Tropical methotrexate and radiation in the treatment of patients with cancer.Cancer Research,24: 1524–1533.PubMedGoogle Scholar
  3. 3.
    Kligerman, M.M., Hellman, S., Von Essen, C.F. (1966), Sequential chemotherapy and radiotherapy: Priliminary results of clinical trial with methotrexate in head and neck cancer.Radiology,86 : 247–250.PubMedGoogle Scholar
  4. 4.
    Jesse, R.H., Villareal, R., Letaye, V. (1964), Intra-arterial infusion for head and neck cancer.Arch. Surg. 88: 618–627PubMedGoogle Scholar
  5. 5.
    Sulliran, R.D., Miller, E. and Sikes, M.P. (1959), Antimetabolic combination cancer chemotherapy: effects of intra-arterial methotrexate intramuscular cetrovarum factor therapy in human cancer.Cancer,12 : 1248–1262.CrossRefGoogle Scholar
  6. 6.
    Papack, R.J., Jacobs, F.M., Foye, L.V. (1963), Systemic therapy with amithopterin in squamous carcinoma of head and neck region.Cancer Chemotherapy Rep. 34–47.Google Scholar
  7. 7.
    Kramer, S. (1969), Use of methotrexate and radiation therapy for advanced cancer of head and neck.Frontiers, Radiation Ther. One. 4: 116–125.Google Scholar
  8. 8.
    Friedman, M., Felix, N., Narvacs, D.F. (1970), The treatment of squamous cell carcinoma of head and neck with combined methotrexate and radiation.Cancer,26: 711–721.PubMedCrossRefGoogle Scholar
  9. 9.
    Pant, G.G., Sanyal, B. and Khanna, N.N. (1973), Sequential treatment of advanced oral carcinoma by methotrexate and radiotherapy.Indian J. Med. Res. 61: 848–855.PubMedGoogle Scholar
  10. 10.
    Fletcher, H.G. ; Jesse, R.H. (1977), The place of radiation in the management of the primary lesion in the head and neck cancer.Cancer,39: 862–887.PubMedCrossRefGoogle Scholar
  11. 11.
    Tarpley, J.L., Chretien, P.B. ; Alexcnder, J.C. (1975), High dose methotrexate as pre-operative adjuvant in treatment of epidermoid carcinoma of head and neck.Am. J. Surg. 130: 481–486.PubMedCrossRefGoogle Scholar
  12. 12.
    Marciai et al., Quoted from Al. Sarraf, M. (1934), Chemotherapy strategies in squamous cell carcinoma of the head and neck.CRC Critical review in Oncology/Haematology,4: 323–354.Google Scholar

Copyright information

© Association of Otolaryngologists of India 1989

Authors and Affiliations

  • Anupam Kumar Asthana
    • 1
  • Rajeev Kumar Jain
    • 2
  • Girish Chandra Pant
    • 1
  • Om Prakash Singh
    • 3
  1. 1.Dept. of Radiotherapy & Radiation Medicine, Institute of Medical SciencesBanaras Hindu UniversityVaranasi
  2. 2.Department of E.N.T., Institute of Medical SciencesBanaras Hindu UniversityVaranasi
  3. 3.Hanuman Prasad Poddar Cancer InstituteGorakhpur

Personalised recommendations