Indian Journal of Otolaryngology

, Volume 41, Issue 1, pp 16–18 | Cite as

Detection of neutrophil inhibition factor (NIF) in patient with carcinoma of larynx using skin-window technique

  • A. K. Kapoor
  • H. Sharma
  • D. Dayal
  • S. P. Agarwal
Original/Main Article


Tumour antigen-induced leucocyte inhibition was studied in vivo in patients with laryngeal carcinomas (squamous-cell type in 13 and transitional cell type in 1 case) and benign tumours (squamous cell papilloma in 2, fibroepithelial polyp in 1 and mixed mesenchymal tumour in 1 case). All the patients were biopsied and autologous tumour-antigen (ATA) was used in vivo skin window test.

Release of of ATA-induced neutrophil inhibition factor (NIF) was detected in 12 of 14 (85.7%) malignant cases. Basophilic chemotaxis occurred in 4 malignant cases, following exposure to ATA. Furthermore, 4 other malignant cases also gave positive ATA-induced delayed hypersensitivity (DH) response. Results of this study suggest possible role of immunological factors in limiting tumour dissemination.


Amyloidosis Tumour Antigen Laryngeal Carcinoma Malignant Case Larynx Cancer 


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Copyright information

© Association of Otolaryngologists of India 1989

Authors and Affiliations

  • A. K. Kapoor
    • 1
  • H. Sharma
    • 2
  • D. Dayal
    • 2
  • S. P. Agarwal
    • 2
  1. 1.Department of PathologyK. G. Medical CollegeLucknow
  2. 2.Department of OtorhinolaryngologyK. G. Medical CollegeLucknow

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