Indian Journal of Otolaryngology

, Volume 41, Issue 1, pp 16–18 | Cite as

Detection of neutrophil inhibition factor (NIF) in patient with carcinoma of larynx using skin-window technique

  • A. K. Kapoor
  • H. Sharma
  • D. Dayal
  • S. P. Agarwal
Original/Main Article


Tumour antigen-induced leucocyte inhibition was studied in vivo in patients with laryngeal carcinomas (squamous-cell type in 13 and transitional cell type in 1 case) and benign tumours (squamous cell papilloma in 2, fibroepithelial polyp in 1 and mixed mesenchymal tumour in 1 case). All the patients were biopsied and autologous tumour-antigen (ATA) was used in vivo skin window test.

Release of of ATA-induced neutrophil inhibition factor (NIF) was detected in 12 of 14 (85.7%) malignant cases. Basophilic chemotaxis occurred in 4 malignant cases, following exposure to ATA. Furthermore, 4 other malignant cases also gave positive ATA-induced delayed hypersensitivity (DH) response. Results of this study suggest possible role of immunological factors in limiting tumour dissemination.


Amyloidosis Tumour Antigen Laryngeal Carcinoma Malignant Case Larynx Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baldwin, R.W. and Robin, R.A. (1976): Factors interfering with immunological rejection of tumours, in ‘Immunological tolerance’.British Medical Bulletin 32 : 118.PubMedGoogle Scholar
  2. 2.
    Bates, S.E., Duen, J.Y. and Tranum, B.L. (1979): Immunological skin testing and interpretations : A plea for uniformity.Cancer 43 : 2306.PubMedCrossRefGoogle Scholar
  3. 3.
    Black, M.M. and Leis, H.P. (1970): Human breast carcinoma, part III. Cellular response to autologus breast cancer : skin-window procedure,New York State Journal of Medicine 15 : 2603.Google Scholar
  4. 4.
    Black, M.M. and Leis, H.P. (1971): Cellular response to autologus breast cancer tissue, correlates with stage and lymphoreticular activity.Cancer 28 : 268.CrossRefGoogle Scholar
  5. 5.
    Black, M.M. and Leis, H.P. (1973): Cellular response to autologus breast cancer tissue.Cancer 32 : 384.PubMedCrossRefGoogle Scholar
  6. 6.
    Cortesina, G., Bussi, M., Morra, B., Beatrice, F., Cavallo, G.P., Fortunato, V Di, Poggio, E., Rendine, S., Sartoris, A., and Landolfo, S. (1983): Specific LIF production in laryngeal cancer patients : evidence of suppressor activity exerted by adherent cells.Tumori 69 : 497–502.PubMedGoogle Scholar
  7. 7.
    Cortesina, G., Cavallo, G.P., Beatrice, F. Sartoris, A., Bussi, M., Morra, B., Fortunato, V Di, Poggio, E. and Rendine S. (1982): Production of leucocyte migration inhibition factor by lymphocytes of larynx cancer patients stimulated by laryngeal carcinoma solubilized membrane antigens.Tumori 68 : 39–46.PubMedGoogle Scholar
  8. 8.
    Dacie, J.V. and Lewis, S.M. (1975): Practical Haematology, 5th edition (ELBS and Churchill Livingstone, Edinburgh) 48–53.Google Scholar
  9. 9.
    Dizon, G. and Southam, C.M. (1963): Abnormal cellular response to skin abrasion in cancer patients.Cancer 16 : 1268.CrossRefGoogle Scholar
  10. 10.
    King, E.J. and Wooton, I.D.P. (1959): Microanalysis in medical biochemistry 3rd edition (J & A Churchill Ltd, London) p 37.Google Scholar
  11. 11.
    Purohit, J.P., Dayal, D., Kapoor, A.K. and Khan, I.U. (1986): Immunopathological correlation with lymph node metastasis in squamous cell carcinoma of larynx and pharynx.Ind. J. Otolaryngology,38 : 98–101.Google Scholar
  12. 12.
    Shaw Henry (1979) : Tumours of larynx, in Scott-Brown’s diseases of Ear Nose and Throat Vol. 4 (Ballantyne J., Groves, J, editors) Butterworths ; p 439–440.Google Scholar

Copyright information

© Association of Otolaryngologists of India 1989

Authors and Affiliations

  • A. K. Kapoor
    • 1
  • H. Sharma
    • 2
  • D. Dayal
    • 2
  • S. P. Agarwal
    • 2
  1. 1.Department of PathologyK. G. Medical CollegeLucknow
  2. 2.Department of OtorhinolaryngologyK. G. Medical CollegeLucknow

Personalised recommendations