The modulation of plasma lipids and lipoproteins during bone marrow transplantation is unrelated to exogenously administered recombinant human granulocyte-mnonocyte colony-stimulating factor (rHu GM-CSF)
We evaluated the effect of exogenously administered recombinant human granulocyte-macrophage colony stimulating factor (rHu GM-CSF) on plasma lipid and lipoprotein concentrations in 28 patients undergoing bone marrow transplantation (BMT). Twenty-one received rHu GM-CSF during the immediate post transplantation period (group 1) and seven did not (group 2). All patients received intravenous hyperalimentation starting at the immediate post-transplantation period until 3–5 days post engraftment. Plasma lipids and lipoproteins, liver and renal function tests and blood counts were determined prior to BMT (baseline levels) and during the immediate and late post transplantation periods. In both groups, marked changes of plasma total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) concentrations were observed. During the immediate post transplantation period, TC levels decreased by 22.2% and 26.2% in groups 1 and 2, respectively. During the same period, HDL-C levels decreased by 41.4% and 37.5% in these two groups. At the late recovery phase TC and HDL-C resumed pre-treatment levels. These changes were in parallel to the fluctuations in total WBC counts. We conclude, therefore, that BMT has a significant transient effect on plasma lipids and lipoproteins. Although this response is unrelated to the exogenous administration of rHu GM-CSF it may be causally related to endogenous cytokines or other, yet unidentified, factors.
KeywordsrHu GM-CSF plasma lipids bone marrow transplantation
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- 4.Ishibashi, S., Inaba, T., Shimano, H., Harada, K., Inoue, K., Mokuno, H., Mori, N., Gotoda, T., Takaku, F. and Yamada, N. (1990) Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocytederived macrophages.J. Biol. Chem. 265, 14109–17.PubMedGoogle Scholar
- 7.Takahashi, M., Nikkuni, K., Moriyama, Y. and Shibata, A. (1991) GM-CSF-mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol.Am. J. Hemat. 36, 1213–4.Google Scholar
- 10.Goldstein, J.L. and Brown, M.S. (1989) Familial hypercho- lesterolemia. In: C.R. Scriver, A.L. Beaudet, W.S. Sly and D. Valle (eds)The Metabolic Basis of Inherited Disease, 6th edn, pp. 1215–50. New York: McGraw-Hill.Google Scholar
- 12.Ishibashi, T., Yokoyama, K., Shindo, J., Hamazaki, Y., Endo, Y., Sato, T., Takahashi, S., Kawarabayasi, Y., Shiomi, M., Yamamoto, T. and Maruyama, Y. (1994) Potent cholesterol-lowering effect by human granulocyte- macrophage colony-stimulating factor in rabbits.Arterioscler. Thromb. 14, 1534–41.PubMedGoogle Scholar
- 14.Holler, E., Kolb, H.J., Mîller, A., Kempeni, J., Liesenfeld, S., Pechumer, H., Lehmacher, W., Ruckdeschel, G., Gleixner, B., Riedner, C., Ledderose, G., Brehm, G., Mitterm’ller, J. and Wilmanns, W. (1990) Increased serum levels of tumor necrosis factor precede major complications of bone marrow transplantation.Blood 75, 1011–16.PubMedGoogle Scholar
- 15.Naparstek, E., Hardan, Y., Ben-Shahar, M., Nagler, A., Or, R., Mumcuoglu, M., Weiss, L., Samuel, S. and Slavin, S. (1992) Enhanced marrow recovery by short perincubation of marrow allografts with human recombinant interleukin- 3 and granulocyte-macrophage colony-stimulating factor.Blood 7, 1673–8.Google Scholar
- 18.Winer, B.J. (1969)Statistical Principles in Experimental Design. New York: McGraw-Hill.Google Scholar
- 21.Foa, R., Guarini, A., Francia de Celle, P., Trentin, L., GillioTos, A., Bellone, G., Carbone, A., Attisano, C., Massaia, M., Raspadori, D., Pizzolo, G., Chisesi, T., Lauria, F. and Semenzato, G. (1992) Constitutive production of tumor necrosis factor-alpha in hairy cell leukemia: possible role in the pathogenesis of the cytopenia(s) and effect of treatment with interferon-alpha.J. Clin. Oncol. 10, 954–9.PubMedGoogle Scholar
- 24.Riikonen, P., Saarinen, U., Teppo, A., Metsarinne, K., Fyhrquist, F. and Jalanko, H. (1988) Cytokine and acute- phase reactant levels in serum of children with cancer admitted for fever and neutropenia.J. Infect. Dis. 166, 432–6.Google Scholar
- 26.Grunfeld, C., Wilking, H., Neese, R., Gavin, L., Moser, A., Gulli, R., Serio, M.K. and Feingold, K. (1989) Persistence of the hypertriglyceridemic effect of tumor necrosis factor despite development of tachyphylaxis to its anorectic/ cachectic effects in rats.Cancer Res. 49, 2554–60.PubMedGoogle Scholar