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Folia Microbiologica

, Volume 48, Issue 5, pp 585–587 | Cite as

Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids

  • K. Waisser
  • K. Dražková
  • J. Čižmárik
  • J. Kaustová
Article

Abstract

A series of 17 hydrochlorides of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the moiety in position 3, were evaluated forin vitro antimycobacterial activity against the strains ofMycobacterium tuberculosis, M. kansasii andM. avium. To describe the structure-antimycobacterial activity relationships (QSAR), an approach based on the Free-Wilson method was employed to express the differences between individual moieties (including propyl and ethyl). The change of ethyl to propyl moiety increases the activity toM. tuberculosis but decreases the antimycobacterial activity to all potentially pathogenic strains under study.

Keywords

Phen Myco Amic Acid Carbamic Acid Alkox 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Čižmárik J., Mazáň Š., Novosedlákova D., Račanská E.: Studies of local anesthetics. CII. Preparation and activity of piperidinepropylesters of alkoxy-substituted phenylcarbamic acids.Českoslov.Farm. 41, 130–132 (1992).Google Scholar
  2. Fujita T., Ban T.: Structure-activity study of phenethylamines as substrates of biosynthetic enzymes of sympathetic transmitters.J.Med.Chem. 14, 148–152 (1971).PubMedCrossRefGoogle Scholar
  3. Waisser K., Čižmárik J., Dražkova K., Kaustova J.: Antimycobacterial effects of pyrrolidinemethylesters of alkoxysubstituted phenylcarbamic acids.Čes.Slov.Farm. 51, 140–144 (2002).Google Scholar
  4. Waisser K., Dražková K., Čižmarik J., Kaustova J.: Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids.Folia Microbiol. 48, 45–50 (2003).CrossRefGoogle Scholar

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2003

Authors and Affiliations

  • K. Waisser
    • 1
  • K. Dražková
    • 1
  • J. Čižmárik
    • 2
  • J. Kaustová
    • 3
  1. 1.Department of Inorganic and Organic ChemistryCharles University, Faculty of PharmacyHradec KrálovéCzechia
  2. 2.Department of Pharmaceutical Chemistry, Faculty of PharmacyComenius UniversityBratislavaSlovakia
  3. 3.Department for Diagnostics of MycobacteriaRegional Institute of Public Health, OstravaOstravaCzechia

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