Biological Trace Element Research

, Volume 26, Issue 1, pp 177–187 | Cite as

Trace elemental content of biological materials

A comparison of NAA and ICP-MS analysis
  • Neil I. Ward
  • Fadi R. Abou-Shakra
  • Steven F. Durrant
Neutron Activation and Related Methods


The advantages and disadvantages of neutron activation analysis (NAA) and inductively coupled plasma-source mass spectrometry (ICP-MS) for the analysis of biological materials is reviewed.

Comparison is made between NAA (instrumental) and ICP-MS (conventional pneumatic solution nebulization and laser ablation) analysis of the biological reference material National Bureau of Standards (NBS) SRM 1577 Bovine Liver. Relatively good agreement is achieved between the results for the 18 elements analyzed by both techniques and those either certified or reported in the literature. Elemental concentrations for Li, Mg, Al, Ca, Cr, Mn, Fe, Cu, Zn, Br, Rb, and Cs are also reported for IAEA Mixed Human Diet (H9), NBS SRM 909 Human Serum, and NBS SRM 1577a Bovine Liver, analyzed by solution nebulization ICP-MS.

Index Entries

NAA ICP-MS multielement analysis biological reference materials 


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Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • Neil I. Ward
    • 1
  • Fadi R. Abou-Shakra
    • 1
  • Steven F. Durrant
    • 1
  1. 1.Department of ChemistryUniversity of SurreyGuildfordUK

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