Abstract
Luteinizing hormone-releasing hormone, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2,2 was synthesized in a stepwise manner by two approaches: the use of insoluble polymeric active esters derived from (4-hydroxy-3-nitro)benzylated polystyrene and that of solubleN,N-dicyclohexylcarbodiimide. The overall yields of the syntheses were 40 and 7%, respectively. The efficiencies of the two synthetic routes, in which identical intermediate peptides were prepared, are compared.
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Fridkin, M., Hazum, E., Kalir, R. et al. Polymeric reagent synthesis of luteinizing hormone-releasing hormone. Journal of Solid-Phase Biochemistry 2, 175–182 (1977). https://doi.org/10.1007/BF02991406
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DOI: https://doi.org/10.1007/BF02991406