Medical Oncology

, Volume 13, Issue 4, pp 195–197 | Cite as

Bronchiolitis obliterans presenting as subcutaneous emphysema and pneumomediastinum: A case report

  • A. Toren
  • R. Or
  • A. Nagler
  • R. Breuer


We describe a woman post allogeneic bone marrow transplantation (BMT), who presented to the emergency room with subcutaneous emphysema and pneumomediastinum as the first manifestation of bronchiolitis obliterans complicating mild chronic graft versus host disease (GVHD). In contrast to other patients with pneumomediastinum described in the literature, this patient suffered from only mild GVHD. She did not receive methotrexate as GVHD prophylaxis, and the peumomediastinum was a presenting manifestation rather than a terminal event. In addition, this is the first description of subcutaneous emphysema with this setting. Therefore, bronchiolitis obliterans should be highly suspected in post-BMT patients presenting with pneumomediastinum and subcutaneous emphysema, and prompt therapy should be initiated.


pneumomediastinum subcutaneous emphysema bronchiolitis obliterans acute myeloid leukaemia bone marrow transplantation absolute neutrophil count graft versus host disease 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • A. Toren
    • 1
  • R. Or
    • 2
  • A. Nagler
    • 2
  • R. Breuer
    • 3
  1. 1.Pediatric Hemato/Oncology DepartmentThe Chaim Sheba Medical Center, affiliated to the Sackler School of Medicine, Tel-Aviv UniversityTel-HashomerIsrael
  2. 2.Department of Bone Marrow TransplantationHadassah University Hospital and the Hebrew UniversityJerusalemIsrael
  3. 3.Pulmonary InstituteHadassah University Hospital and the Hebrew UniversityJerusalemIsrael

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