Production of prostaglandin e by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue

  • F. ČULO
  • I. Klapan
  • V. Katic
  • T. Kolak
  • B. Bakula


The production of prostaglandin Eex vivo was studied in samples of 31 squamous cell carcinomas of the head and neck (SCCHN) and 12 adenocarcinomas of gastrointestinal tract (ACGI). As a control, the PGE production was measured in 22 samples of noninvolved mucosa in patients with SCCHN and 12 samples of gastrointestinal mucosas. The mean PGE production by SCCHN was significantly higher than in normal mucosa. Furthermore, the PGE production by tumors which recurred or spread to regional lymph node within 18 months after surgery was higher than in tumors which did not recur within that interval. Also, production of PGE by noninvolved mucosa was significantly higher in patients in which tumor recurred after surgery than in patients which were tumor free. On the other hand, the mean production of PGE by ACGI was not different from that of normal mucosa. These data show that determination of PGE production might have prognostic significance in SCCHN.

Key Words

Head and neck cancer Gastrointestinal cancer PGE 


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  1. 1.
    Goodwin J S, Ceuppens J L: PRostaglandis, cellular immunity and cancer.Prostaglandins Leukotriens Cancer 4, 1 (1985).Google Scholar
  2. 2.
    Bennett A, Charlier E M, McDonald A M, Simpson J S, Stamford I F, Zebro T: Prostaglandins and breast cancer.Lancet ii, 624, (1977).CrossRefGoogle Scholar
  3. 3.
    Bishop H, Haynes J, Evans D, Elston C, Johnson J, Blarney V: Radioimmunoassay (RIA) of prostaglandin E2 (PGE2) in primary breast cancer and its relationship to histologic grade.Clin Oncol 6, 380 (1980).Google Scholar
  4. 4.
    Rolland P H, Martin P M, Jacquemier J, Rolland A M, Toga M: Prostaglandin in human breast cancer. Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells.J Natl Cancer Inst 64, 1061 (1980).PubMedGoogle Scholar
  5. 5.
    Vanderveen E E, Grekin R C, Swanson N A, Kragballe K: Arachidonic acid metabolites in cutaneous carcinoma.Arch Dermatol 122, 407 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    Hendrick A M, Mitchell M D, Harris A L: Plasma prostaglandins in lung cancer.Eur J Cancer Clin Oncol 24, 1069 (1988).PubMedCrossRefGoogle Scholar
  7. 7.
    Karmali R A, Welt S, Thaler H T, Lefevre F: Prostaglandins in breast cancer:relationship to disease stage and hormone status.Br J Cancer 48, 689 (1983).PubMedGoogle Scholar
  8. 8.
    Malachi T, Chaimoff C, Feller N, Halbrecht I: PGE2 and cyclic AMP in tumor and plasma of breast cancer patients.J Cancer Res Clin Oncol 102, 71 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    Bennett A, Carrol M A, Melhuish P B, Stamford I F:Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin.Br J Cancer 2, 245 (1985).Google Scholar
  10. 10.
    Fulton AM: In vitro effects of indomethacin on the growth of murine mammary tumors.Cancer Res 44, 2416 (1984).PubMedGoogle Scholar
  11. 11.
    Hubbard N E, Chapkin R S, Erickson K L: Inhibition of growth and linoleate-enhanced metastases of a transplant-able mouse mammary tumor by indomethacin.Cancer Res 43, 111 (1988).Google Scholar
  12. 12.
    Lynch N R, Casatles M, Astonin M, Salomon J C:Mechanism of inhibition of tumor growth by aspirin and indomethacin.Br J Cancer 38, 503 (1978).PubMedGoogle Scholar
  13. 13.
    Santoro M G, Philpott G W, Jaffe B M: Inhibition of tumor growth in vivo and in vitro by prostaglandin E.Nature 263, 777 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    Santoro M G, Jaffe B M: Inhibition of Friend erythroleukaemia cell tumors in vivo by a synthetic analogue of prostaglandin E2.Br J Cancer 39, 408 (1979).PubMedGoogle Scholar
  15. 15.
    Hubbard W C, Alley C, McLemore T L, Boyd MR:Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate and ovarian tumors.Cancer Res 48, 4770 (1988).PubMedGoogle Scholar
  16. 16.
    Berlinger N T: Deficient immunity in head and neck cancer due to excessive monocyte production of prostaglandins.Laryngoscope 94, 1407 (1984).PubMedCrossRefGoogle Scholar
  17. 17.
    Bennett A, Carter L, Stamford I F, Tanner N S B:Prostaglandin-like material extracted from squamous carcinomas of the head and neck.BrJ Cancer 41, 204 (1980).Google Scholar
  18. 18.
    Jung T T K, Berlinger N T, Juhn K: Prostaglandins in squamous cell carcinoma of the head and neck:a preliminary study.Laryngoscope 95, 307 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    Johnson J T, Rabin B S, Wagner R L: Prostaglandin E2 of the upper aerodigestive tract.Ann Otol Rinol Laryngol 96, 213 (1987).Google Scholar
  20. 20.
    Klapan I, Snyderman C H, Heo D S, Johnson J T, Whiteside T L: Prostaglandin production and immunosuppression by squamous cell carcinomas of the head and neck.Arch Otolaryngol Head Neck Surg (submitted) (1991).Google Scholar
  21. 21.
    Snyderman C H, Klapan I, Heo D S, Wagner R, Johnson J T, Whiteside T L: In vitro production of prostaglandin E2 by squamous cell carcinoma of the head and neck.Arch Otolaryngol Head Neck Surg (submitted) (1991).Google Scholar
  22. 22.
    Pinto S, Gallo O, Dilaghi M, Gallina E, Giannini A, Coppo M, Pannincia R, Prisco D, Abbate R: Prostaglandins in squamous cell carcinoma of the larynx:tumor and peritumor synthesis.Prostaglandins Leukotriens Essential Fatty Acids 39, 53 (1990).CrossRefGoogle Scholar
  23. 23.
    Botha J H, Robinson K M, Ramchurren N, Reddi K, Mormon R J: Human oesophageal carcinoma cell lines: prostaglandin production, biological properties and behaviour in nude mice.JNCI 76, 1053 (1986).PubMedGoogle Scholar
  24. 24.
    El Atar T M A, Lin H S, Vanderhoek J Y: Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans.Cancer Letters 27, 255 (1985).CrossRefGoogle Scholar
  25. 25.
    Honn K, Cicone B, Skoff A: Prostacycline: A potent antimetastatic agent.Science 212, 1270 (1981).PubMedCrossRefGoogle Scholar
  26. 26.
    Slotman G J: Plasma tromboxane A2 and prostacyclin concentration in squamous cell carcinoma of the head and neck.J Surg Oncol 38, 33 (1988).PubMedCrossRefGoogle Scholar
  27. 27.
    Bennett A, Civier A, Hensby C N, Melhuish, Stamford I F: Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissue.Gut 28, 315 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • F. ČULO
    • 1
  • I. Klapan
    • 2
  • V. Katic
    • 2
  • T. Kolak
    • 3
  • B. Bakula
    • 3
  1. 1.Department of Physiology and ImmunologyThe School of MedicineZagrebCroatia
  2. 2.Departments of Otorinolaryngology, The School of MedicineUniversity of ZagrebZagrebCroatia
  3. 3.Department of Surgery Hospital “Sveti Duh”ZagrebCroatia

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