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Gastroenterologia Japonica

, Volume 28, Supplement 5, pp 71–75 | Cite as

Anti-HCV immunoglobulin M antibody in patients with acute and fulminant hepatitis C

  • S. M. Fazle Akbar
  • Morikazu Onji
  • Norio Horiike
  • Yasuyuki Ohta
Serum Markers and Clinical Aspects HCV

Summary

To determine whether detection of IgM type antibody (Ab) to hepatitis C virus (HCV) antigens would be useful in the early diagnosis of type C acute hepatitis (AH) or fulminant hepatitis (FH), we assayed serum IgM and IgG type Abs to nonstructural (C100-3) and core (AR 142) antigens of HCV in patients with type C hepatitis. Of 8 patients with AH, anti-C100-3 IgM and anti-AR 142 IgM were positive in 1 and 6 patients, respectively. Early appearance of Anti-AR 142 IgM was observed in all of these 6 patients, and in 4 anti-AR 142 IgM was the sole serological marker of HCV infection during the acute-phase. However, the anti-AR 142 IgM response was rather persistent, not transient in AH. Only 1 patient with AH was positive for anti-C100-3 IgM, and this patient became positive for anti-AR 142 IgM 3 months before the appearance of anti-C100-3 IgM. The titre of anti-AR 142 IgM in AH was not dependent on the activity of hepatitis or on the duration. Anti-AR 142 IgM was also positive in 30–75% cases with chronic HCV carriers. Thus it is suggested that the detection of anti-AR 142 IgM may contribute to the early diagnosis of type C AH, although the appearance of this marker in chronic HCV carriers limits its usefulness as the sole serological marker of acute HCV infection.

Keywords

Hepatitis Acute Hepatitis Chronic Persistent Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Japanese Society of Gastroenterology 1993

Authors and Affiliations

  • S. M. Fazle Akbar
    • 1
  • Morikazu Onji
    • 1
  • Norio Horiike
    • 1
  • Yasuyuki Ohta
    • 1
  1. 1.Third Department of Internal MedicineEhime University School of MedicineEhimeJapan

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