Medical Oncology

, Volume 13, Issue 1, pp 43–61 | Cite as

Efficacy and toxicity of radiation in preparative regimens for pediatric stem cell transplantation. II: Deleterious consequences

  • Thomas D. Miale
  • Suebsuk Sirithorn
  • Syed Ahmed


There has been a dramatic improvement in the treatment of both allogeneic and autologous stem cell transplants, especially in children and young adults. However, attempts to apply more intensive conditioning treatments to the more refractory pediatric malignancies have also increased the risks of deleterious consequences. This review examines the risks, and reports important variations in the toxic effects of using different conditioning techniques.


bone marrow transplantation busulfan cyclophosphamide pediatrics stem cells total body irradiation 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • Thomas D. Miale
    • 1
    • 2
    • 4
  • Suebsuk Sirithorn
    • 1
    • 3
  • Syed Ahmed
    • 2
  1. 1.Departments of PediatricsUniversity of Tennessee Medical CenterKnoxville
  2. 2.Departments of Internal MedicineUniversity of Tennessee Medical CenterKnoxville
  3. 3.Department of PediatricsBhumibol Adulyadej Hospital, R.T.A.F.BangkokThailand
  4. 4.Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry IIKarolinska InstituteStockholmSweden

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