Attention deficit hyperactivity disorder (ADHD) is a developmental, neurobehavioral syndrome with an onset in childhood. The aim of this study was to investigate the existence of regional perfusion changes in ADHD by means of Tc-99m HMPAO brain SPECT. Thirteen children with a diagnosis of ADHD and 7 healthy, age-matched controls were included in this study. Hypoperfusion was observed on the right temporal cortex in 9, and on the left temporal cortex in 3 children. The distribution of the lesions showed right lateral temporal cortex involvement in 3, right medial temporal cortex in 9 and left medial temporal cortex in 8 children. The distribution of the lesions showed right lateral temporal cortex involvement in 3, right medial temporal cortex in 9 and left medial temporal cortex in 8 children. Asymmetric perfusion was seen on the caudate nucleus in 4, on the thalamus in 3 and on the frontal cortex in 6 children. There was a significant difference between children with ADHD and controls in right medial temporal cortex: cerebellum and righ lateral temporal cortex: cerebellum ratios. Hypoperfusion in the right medial temporal cortex was significantly and inversely correlated with Du Paul teachers’ questionnaire rating scale (r=−0.71, p=0.0006). It has been postulated that difficulty in self regulating response to stimuli in ADHD is mediated by underfunctioning of the orbital frontal cortex and subsequent connection to the limbic system. Decreased temporal cortex perfusion may dysfunction of the limbic system or the orbito-frontal-limbic axis.
ADHD technetium-99m HMPAO brain SPECT
This is a preview of subscription content, log in to check access.
Zametkin AJ, Liotta W. The neurobiology of ateentiondeficit/hyperactivity disorder.J Clin Psychiatry 1998; 59: (Suppl 7): 17–23.PubMedGoogle Scholar
Conners CK. Rating scales in attention-deficit/hyperactivity disorder: use in assessment and treatment monitoring.J Clin Psychiatry 1998; 59 (supply 7): 24–30.PubMedGoogle Scholar
Conners CK. Conners abbreviated symptom questionnaire. North Tonawanda, NY, Multi Health Systems 1994Google Scholar
Du Paul GJ. Parent and teacher rating of ADHD symptoms: Psychometric properties in a community-based sample.J Clin Child Psychol 1991; 20: 245–253.CrossRefGoogle Scholar
Wechsler D.WISC-R Manual: Wechsler intelligence scale for children-revised. New York, NY, The Psychological Corp., 1974.Google Scholar
Biederman J, New Corn J, Sprich S. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders.Am J Psychiatry 1991; 148: 564–577.PubMedGoogle Scholar
Giedd JN, Castellanos FX, Casey BJ, Kozuch P, King AC, et al. Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder.Am J Psychiatry 1994; 151: 665–669.PubMedGoogle Scholar