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Annals of Nuclear Medicine

, Volume 16, Issue 5, pp 329–335 | Cite as

Serial assessment of left ventricular performance at rest and during bicycle exercise by ECG-gated myocardial perfusion SPECT

  • Shin-ichiro Kumita
  • Keiichi Cho
  • Hidenobu Nakajo
  • Masahiro Toba
  • Kazuyoshi Akiyama
  • Yoshimitsu Fukushima
  • Sunao Mizumura
  • Tatsuo Kumazaki
  • Junko Sano
  • Kazuo Munakata
  • Hiroshi Kishida
  • Teruo Takano
Original Articles

Abstract

The present study evaluates left ventricular performance during exercise by ECG-gated myocardial perfusion SPECT with short-time data collection. Methods: The study population consisted of 10 healthy volunteers (Group N) and 9 patients with ischemic heart disease (Group I). Seven patients in Group I had a history of prior myocardial infarction. Rest ECG-gated SPECT was performed 40 min after an injection of Tc-99m-tetrofosmin (555–740 MBq). After resting data acquisition, Group N underwent up to two 5-min stages of exercise (75 and 125 watts) on a detachable bicycle ergometer. The Group I patients all underwent symptom-limited, maximal testing on the ergometer. ECG-gated SPECT data were acquired from both groups for 3 min at rest and during the last 3 min of each exercise stage. Results: Significant increases occurred in LVEF from rest to peak stress in both groups (from 55.4±5.8 to 66.6±4.1% in group N, p<0.0001; from 49.0±12.8 to 56.7±13.8% in Group I, p<0.001). The LVESV values significantly decreased to peak stress in Group N (from 49.9±13.1 to 37.8±10.0 ml, p<0.0001), whereas LVEDV did not change (from 110.6±18.9 to 112.0±19.0 ml). In contrast, the LVESV values at rest and under peak stress were similar in Group I (from 52.6±23.9 to 51.7±31.4 ml) and LVEDV in Group I at peak exercise tended to increase (from 102.8±36.7 to 111.3±39.0 ml). The changes in LVESV from rest to peak stress were significantly different between Groups N and I (−12.1±6.3 vs.−0.9±11.6 ml, p<0.02). Conclusion: ECG-gated SPECT with short-time data collection can assess left ventricular function during exercise and may offer useful information for evaluating patients with ischemic heart disease.

Key words

99mTc-tetrofosmin ECG-gated SPECT bicycle exercise ischemic heart disease 

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Copyright information

© Springer 2002

Authors and Affiliations

  • Shin-ichiro Kumita
    • 1
  • Keiichi Cho
    • 1
  • Hidenobu Nakajo
    • 1
  • Masahiro Toba
    • 1
  • Kazuyoshi Akiyama
    • 1
  • Yoshimitsu Fukushima
    • 1
  • Sunao Mizumura
    • 1
  • Tatsuo Kumazaki
    • 1
  • Junko Sano
    • 2
  • Kazuo Munakata
    • 2
  • Hiroshi Kishida
    • 2
  • Teruo Takano
    • 2
  1. 1.Department of RadiologyNippon Medical SchoolTokyoJapan
  2. 2.First Department of Internal MedicineNippon Medical SchoolTokyoJapan

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