Advertisement

Fiber and cancer

  • David Kritchevsky
Article
  • 50 Downloads

Abstract

The role of dietary fiber in colon cancer is still not clear. Ecological studies suggested a protective role for high fiber intake, but more recent analysis shows similar intakes of dietary fiber in populations with high or low incidence of colon cancer. Case-control studies generally do not support a protective role for fiber. The data suggest that the effects of fiber must be considered in the context of the total diet and interactions of dietary components. A role for levels of energy intake is not excluded.

Key words

Colon cancer Diet Dietary fiber 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Higginson J, Oettle A G: Cancer incidence in the Bantu and Cape coloured races in South Africa: report of a cancer survey in the Transvaal.J natn Cancer Inst 24, 589 (1960).Google Scholar
  2. 2.
    Burkitt D P: Epidemiology of cancer of the colon and rectum.Cancer 28, 3 (1971).PubMedCrossRefGoogle Scholar
  3. 3.
    Pilch S M (ed):Review of Physiological Effects and Health Consequences of Dietary Fiber. Bethesda, MD, FASEB (1987).Google Scholar
  4. 4.
    Committee on Diet, Nutrition and Cancer:Diet, Nutrition and Cancer. Washington, DC, National Academy Press (1982).Google Scholar
  5. 5.
    Klurfeld D M, Kritchevsky D: Dietary fiber and human cancer: critique of the literature.Adv exp med Biol 206, 119 (1986).PubMedGoogle Scholar
  6. 6.
    Cummings J H, Bingham S A: Dietary fibre, fermentation and large bowel cancer.Cancer Surveys 6, 601 (1987).PubMedGoogle Scholar
  7. 7.
    Rogers A E, Longnecker M P: Biology of disease. Dietary and nutritional influences on cancer: a review of epidemiological and experimental data.Lab Invest 59, 729 (1988).PubMedGoogle Scholar
  8. 8.
    Byers T: Diet and cancer. Any progress in the interim?Cancer 62, 1713 (1988).PubMedCrossRefGoogle Scholar
  9. 9.
    Manousos O, Day N E, Trichopolous D, Gerovassilis F, Tzonou A, Polychronopoulou A: Diet and colorec- tal cancer: a case control study in Greece.Int J Cancer 32, 1 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    Pickle L W, Greene M H, Ziegler R G, Toledo A, Hoover R, Lynch H T, Fraumeni J F Jr: Colorectal cancer in rural Nebraska.Cancer Res 44, 363 (1984).PubMedGoogle Scholar
  11. 11.
    Potter J D, McMichael A J: Diet and cancer of the colon and rectum: a case-control study.J natn Cancer Inst 76, 557 (1986).Google Scholar
  12. 12.
    Kune S, Kune G A, Watson L F: Case control study of dietary etiological factors: the Melbourne colorectal cancer study.Nutr Cancer 9, 21 (1987).PubMedGoogle Scholar
  13. 13.
    Jensen O M, MacLennon R, Wahrendorf J: Diet, bowel function, fecal characteristics and large bowel cancer in Denmark and Finland.Nutr Cancer 4, 5 (1982).PubMedCrossRefGoogle Scholar
  14. 14.
    Slattery M L, Sorenson A W, Mahoney A W, French T K, kritchevsky D, Street J C: Diet and colon cancer: assessment of risk by fiber type and food source.J natn Cancer Inst 80, 1474 (1988).CrossRefGoogle Scholar
  15. 15.
    Bitner A S, Harris L E, Campbell W F: Rapid n-methylimidazole catalyzed acetylation of plant cell wall sugars.J Agric Food Chem 28, 1242 (1980).CrossRefGoogle Scholar
  16. 16.
    Bitner A S: Alkali-soluble phenolic acids from xylan fraction isolated from reed canary grass.J Dairy Sci 66, 920 (1983).CrossRefGoogle Scholar
  17. 17.
    Heilbrun L K, Nomura A, Hankin J H, Stemmermann G N: Diet and colorectal cancer with special reference to fiber intake.Int J Cancer 44, 1 (1989).PubMedCrossRefGoogle Scholar
  18. 18.
    Stemmermann G N, Nomura A M Y, Heilbrun L K: Dietary fat and risk of colorectal cancer.Cancer Res 44, 4633 (1984).PubMedGoogle Scholar
  19. 19.
    Lee H P, Gourley L, Duffy S W, Estève J, Lee J, Day N E: Colorectal cancer and diet in an Asian population - a case-control study among Singapore Chinese,Int J Cancer 43, 1007 (1989).PubMedCrossRefGoogle Scholar
  20. 20.
    DeCosse J J, Miller H H, Lesser M L: Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyps.J natn Cancer Inst 81, 1290 (1989).CrossRefGoogle Scholar
  21. 21.
    Minowa M, Bingham S, Cummings J H: Dietary fibre intake in Japan.Human Nutr: Applied Nutr 37A, 113 (1983).Google Scholar
  22. 22.
    Kuratsune M, Honda T, Englyst H N, Cummings J H: Dietary fiber in the Japanese diet as investigated in connection with colon cancer risk.Japan J Cancer Res 77, 736 (1986).Google Scholar
  23. 23.
    Walker A R P, Walker B F, Walker A J: Faecal pH, dietary fibre intake and proneness to colon cancer in four South African populations.Br J Cancer 53, 489 (1986).PubMedGoogle Scholar
  24. 24.
    Glober G A, Nomura A, Kamiyama S, Shimoda A, Abba B C: Bowel transit time and stool weight in populations with different colon cancer risks.Lancet 2, 110 (1977).PubMedCrossRefGoogle Scholar
  25. 25.
    Reddy B S, Hedges A R, Laakso K, Wynder E L: Metabolic epidemiology of large bowel cancer.Cancer 42, 2832 (1978).PubMedCrossRefGoogle Scholar
  26. 26.
    Hill M J, Drasar B S, Aries V C, Crowther J S, Hawksworth G, Williams R E O: Bacteria and the aetiology of cancer of the large bowel.Lancet 1, 95 (1971).PubMedCrossRefGoogle Scholar
  27. 27.
    Eastwood M A, Hamilton D: Studies on the adsorption of bile salts to non-absorbed components of diet.Biochim biophys Acta 152, 165 (1968).PubMedGoogle Scholar
  28. 28.
    Story J A, Kritchevsky D: Comparison of the binding of various bile acids and bile salts by several types of fiber.J Nutr 106, 1292 (1976).PubMedGoogle Scholar
  29. 29.
    Nigro N D, Bhadrachari N, Chomchai C: A rat model for studying colonic cancer: effect of cholestyramine on induced tumors.Dis Colon Rectum 16, 438 (1973).PubMedCrossRefGoogle Scholar
  30. 30.
    Kritchevsky D, Klurfeld D M: Fat and cancer, in Newell G R, Ellison N M (eds):Nutrition and Cancer Etiology and Treatment, pp. 173–188. New York, Raven Press (1981).Google Scholar
  31. 31.
    MacDonald I A, Webb G R, Mahony D E: Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh Day Adventists, control subjects and bowel cancer patients.Am J clin Nutr 31, S233 (1978).PubMedGoogle Scholar
  32. 32.
    Hagopian H K, Riggs M G, Swartz L A, Ingram V M: Effect of n-butyrate on DNA synthesis in chick fibro-blasts and HeLa cells.Cell 12, 855 (1977).PubMedCrossRefGoogle Scholar
  33. 33.
    Kim Y S, Tsao D, Morita A, Bella A: Effect of sodium butyrate on three human colorectal adenocarcinoma cell lines in culture, in Malt R A, Williamson R C N (eds):Colon Carcinogenesis, pp. 317–323. Lancaster, U.K., MTP Press (1982).Google Scholar
  34. 34.
    Southgate D A T, Durnin J V G A: Caloric conversion factors. An experimental reassessment of the factors used in the calculation of the energy value of human diets.Br J Nutr 24, 517 (1970).PubMedCrossRefGoogle Scholar
  35. 35.
    Kelsay J L, Behall K M, Prather E S: Effect of fiber from fruits and vegetables on metabolic responses of human subjects. L Bowel transit time, number of defecations, fecal weight, urinary excretions of energy and nitrogen and apparent digestibilities of energy, nitrogen and fat.Am J clin Nutr 31, 1149 (1978).PubMedGoogle Scholar
  36. 36.
    Heaton K W, Emmett P M, Henry C L, Thornton J R, Manhire A, Hartog M: Not just fibre: the nutritional consequences of refined carbohydrate foods.Human Nutr: Clin Nutr 37C, 31 (1983).Google Scholar
  37. 37.
    Kritchevsky D, Klurfeld D M: Influence of caloric intake on experimental carcinogenesis: a review.Adv exp med Biol 206, 55 (1986).PubMedGoogle Scholar
  38. 38.
    Klurfeld D M, Weber M M, Kritchevsky D: Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat.Cancer Res 47, 2759 (1987).PubMedGoogle Scholar
  39. 39.
    Klurfeld D M, Welch C B, Einhorn E, Kritchevsky D: Inhibition of colonic tumor promotion by caloric restriction or exercise in rats.FASEB J 2, A433 (1988).Google Scholar
  40. 40.
    Lyon J L, Mahoney A W, West D W, Gardner J W, Smith K R, Sorenson A W, Stanish W: Energy intake: its relationship to colon cancer risk.J natl Cancer Inst 78, 853 (1987).PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • David Kritchevsky
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA

Personalised recommendations