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Annals of Nuclear Medicine

, Volume 15, Issue 3, pp 293–296 | Cite as

Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia

  • Norio Takahashi
  • Yasuhisa Fujibayashi
  • Yoshiharu Yonekura
  • Michael J. Welch
  • Atsuo Waki
  • Tatsuro Tsuchida
  • Norihiro Sadato
  • Katsuya Sugimoto
  • Akira Nakano
  • Jong-Dae Lee
  • Harumi Itoh
Short Communication

Abstract

Copper-62 labeled diacetyl-bis (N 4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of62Cu-ATSM for myocardial ischemia,62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased62Cu-ATSM uptake, although abnormal18F-FDG uptake was seen in 4 patients. This preliminary study suggests that62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.

Key words

copper-62 ATSM hypoxia coronary artery disease fluorine-18 FDG PET 

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Copyright information

© Springer 2001

Authors and Affiliations

  • Norio Takahashi
    • 4
  • Yasuhisa Fujibayashi
    • 1
  • Yoshiharu Yonekura
    • 1
  • Michael J. Welch
    • 3
  • Atsuo Waki
    • 1
  • Tatsuro Tsuchida
    • 4
  • Norihiro Sadato
    • 1
  • Katsuya Sugimoto
    • 4
  • Akira Nakano
    • 2
  • Jong-Dae Lee
    • 2
  • Harumi Itoh
    • 4
  1. 1.Biomedical Imaging Research CenterFukui Medical UniversityFukuiJapan
  2. 2.First Department of Internal MedicineFukui Medical UniversityFukuiJapan
  3. 3.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA
  4. 4.Department of RadiologyFukui Medical UniversityFukuiJapan

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