Biological Trace Element Research

, Volume 6, Issue 6, pp 519–530 | Cite as

Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat

  • Gregory D. Miller
  • Thomas F. Massaro
  • Ellen Koperek
  • Edward J. Massaro


Effects of low level lead (Pb) exposure on the time-dependent organ-tissue distribution of zinc (Zn), iron (Fe), copper (Cu), and calcium (Ca) were investigated in the neonatal rat. Pups were exposed to Pb acetate (50 mg/kg) via intragastric intubation at 3-d intervals from day 6 postpartum to day 18. This level of Pb exposure had no significant effect on body weight. Exposure to Pb resulted in an alteration of the normal, time-dependent organ distribution of the essential elements and significantly lower concentrations of Zn were found in brain, liver, kidney, and femur of Pb-treated animals.

Index Entries

Neonatal Pb exposure Pb and essential element interactions 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H. L. Needleman, L. E. Gunnoe, A. Levition, R. Reed, H. Peresie, C. Mahev, and P. Barrett,N. Engl. J. Med. 300, 689 (1979).PubMedGoogle Scholar
  2. 2.
    B. De La Burde, and M. S. Choate,J. Pediatr. 87, 638 (1975).PubMedCrossRefGoogle Scholar
  3. 3.
    O. David,Environ, Health Perspect. 7, 17 (1974).CrossRefGoogle Scholar
  4. 4.
    R. Baloh, R. Strum, B. Green, and G. Gleser,Arch. Neural. 32, 326 (1975).Google Scholar
  5. 5.
    D. Brown,Toxicol. Appl, Pharmacol. 32, 628 (1975).CrossRefGoogle Scholar
  6. 6.
    K. M. Jason and C. K. Kellogg,Pharmacol. Biochem. Behav. 15, 641 (1981).PubMedCrossRefGoogle Scholar
  7. 7.
    R. Kishi, T. Ikeda, H. Miyake, E. Uchino, T. Tsuzki, and K. Inoue,Arch. Environ. Health. 38, 25 (1983).PubMedGoogle Scholar
  8. 8.
    G. D. Miller, T. F. Massaro, R. W. Granlund, and E. J. Massaro,J. Toxicol. Environ. Health 11, 121 (1983).PubMedGoogle Scholar
  9. 9.
    I. A. Michaelson and M. W. Sauerhoff,Life Sci. 13, 417 (1973).CrossRefGoogle Scholar
  10. 10.
    T. F. Massaro and P. Widmayer,Am. J. Clin. Nutr. 34, 864 (1981).PubMedGoogle Scholar
  11. 11.
    T. F. Massaro, M. Mohs, and G. Fosmire,Physiol. Behav. 25, 117 (1982).CrossRefGoogle Scholar
  12. 12.
    G. D. Miller, C. C, Reddy, T. F. Massaro, and E. J. Massaro,The Toxicologist 2, 81 (1982).Google Scholar
  13. 13.
    M. S. Clegg, C. L. Keen, B. Lönnerdal, and L. S. Hurley,Biol. Trace Elem. Res. 3, 107 (1981).CrossRefGoogle Scholar
  14. 14.
    F. J. Fernandez,Clin. Chem. 21, 558 (1975).PubMedGoogle Scholar
  15. 15.
    J. J. Helwig and K. A. Council (ed.), SAS Institute, Inc., Cary, NC, 1979.Google Scholar
  16. 16.
    W. W. Daniel,Applied Nonparametric Statistics, Houghton Mifflin Co., Boston, MA, 1978.Google Scholar
  17. 17.
    S. R. Overman, L. Zimmer, and D. E. Woolley,Neurotoxicol. 2, 725 (1981).Google Scholar
  18. 18.
    G. H. Hirsch,Toxicol. Appl. Pharm. 25, 84 (1973).CrossRefGoogle Scholar
  19. 19.
    S. Overman,Toxicol. Appl. Pharmacol. 41, 459 (1977).CrossRefGoogle Scholar
  20. 20.
    B. P. Fine, B. S. Jortner, A. Ty, D. Cause, and S. M. Lyon,Environ. Res. 19, 215 (1979).PubMedCrossRefGoogle Scholar
  21. 21.
    B. Fowler, C. Kimmel, J. Woods, E. McConell, and L. Grant,Toxicol. Appl. Pharmcaol. 56, 59 (1980).CrossRefGoogle Scholar
  22. 22.
    R. A. Goyer,Curr. Top. Pathol. 55, 147 (1971).PubMedGoogle Scholar
  23. 23.
    D. D. Choie and G. W. Richter, inLead Toxicity, R. L. Singhal and J. A. Thomas, eds., 1980, pp. 187–212.Google Scholar
  24. 24.
    D. D. Choie, W. Goetz, and L. B. Young,Beitr. Pathol. 155, 197 (1975).PubMedGoogle Scholar
  25. 25.
    P. Mistry, G. W. Lucier, and B. A. Fowler,Fed. Proc. 41 (3), 527 (1982).Google Scholar
  26. 26.
    C. L. Keen and L. S. Hurley,Mech. Ageing Dev. 13, 161 (1980).PubMedCrossRefGoogle Scholar
  27. 27.
    J. A. Blair, I. P. L. Coleman, and M. E. Hilburn,J. Physiol. 286, 343 (1979).PubMedGoogle Scholar
  28. 28,.
    K. R. Mahaffey, inLead Toxicity, R. L. Singhal and J. A. Thomas, eds., 1980, pp. 425–460.Google Scholar
  29. 29.
    I. A. Michaelson, inLead Toxicity, R. L. Singhal and J. A. Thomas, eds., 1980, pp. 301–365.Google Scholar
  30. 30.
    C. L. Keen, B. Löonnerdal, M. Clegg, and L. S. Hurley,J. Nutr. 111, 226 (1981).PubMedGoogle Scholar
  31. 31.
    A. J. Vander, D. L. Taylor, K. Kalitis, D. R. Mouw, and W. Victery,Am. J. Physiol. 233, F532 (1977).Google Scholar
  32. 32.
    W. Victery, D. Thomas, P. Schoeps, and A. J. Vander,Biol. Trace Elem. Res. 4, 211 (1982).CrossRefGoogle Scholar
  33. 33.
    R. J. Kavlock and J. A. Gray,Biol. Neonate 41, 279 (1982).PubMedCrossRefGoogle Scholar
  34. 34.
    D. A. Cory-Slechta and T. Thompson,Toxicol. Appl. Pharmacol. 47, 157 (1979).Google Scholar
  35. 35.
    L. D. Grant, C. A. Kimmel, G. L. West, C. M. Martinez-Varges, and J. L. Howard,Toxicol. Appl. Pharmacol. 56, 42 (1980).PubMedCrossRefGoogle Scholar
  36. 36.
    E. D. Levin and R. E. Bowman,Neurobehav. Toxicol. Teratol. 5, 391 (1983).PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1984

Authors and Affiliations

  • Gregory D. Miller
    • 1
  • Thomas F. Massaro
    • 2
  • Ellen Koperek
    • 1
  • Edward J. Massaro
    • 2
  1. 1.Nutrition Program, College of Human DevelopmentThe Pennsylvania State UniversityPennsylvania
  2. 2.Center for Air Environment Studies, Fenske LaboratoryThe Pennsylvania State UniversityPennsylvania

Personalised recommendations