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Biological Trace Element Research

, Volume 6, Issue 6, pp 519–530 | Cite as

Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat

  • Gregory D. Miller
  • Thomas F. Massaro
  • Ellen Koperek
  • Edward J. Massaro
Article

Abstract

Effects of low level lead (Pb) exposure on the time-dependent organ-tissue distribution of zinc (Zn), iron (Fe), copper (Cu), and calcium (Ca) were investigated in the neonatal rat. Pups were exposed to Pb acetate (50 mg/kg) via intragastric intubation at 3-d intervals from day 6 postpartum to day 18. This level of Pb exposure had no significant effect on body weight. Exposure to Pb resulted in an alteration of the normal, time-dependent organ distribution of the essential elements and significantly lower concentrations of Zn were found in brain, liver, kidney, and femur of Pb-treated animals.

Index Entries

Neonatal Pb exposure Pb and essential element interactions 

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Copyright information

© Humana Press Inc. 1984

Authors and Affiliations

  • Gregory D. Miller
    • 1
  • Thomas F. Massaro
    • 2
  • Ellen Koperek
    • 1
  • Edward J. Massaro
    • 2
  1. 1.Nutrition Program, College of Human DevelopmentThe Pennsylvania State UniversityPennsylvania
  2. 2.Center for Air Environment Studies, Fenske LaboratoryThe Pennsylvania State UniversityPennsylvania

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