Skip to main content
SpringerLink
Log in

Comparison of201Tl-chloride SPECT with99mTc-MIBI SPECT in the depiction of malignant head and neck tumors

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Objective

Comparison of201T1 chloride SPECT (Tl-SPECT) with99mTc-MIBI SPECT (MIBI-SPECT) in the depiction of malignant head and neck tumors was prospectively studied.

Methods

Forty-one patients with various tumors of the head and neck were included in this prospective study. Histologically, 36 patients had squamous cell carcinomas, 3 undifferentiated carcinomas, 1 transitional cell carcinoma, and 1 MALT lymphoma. All patients underwent a simultaneous dual-isotope SPECT of the head and neck with201Tl and99mTc-MIBI. Dual-isotope SPECT for early (n = 41) and delayed acquisition (n = 21) was performed. Qualitatively, 3 observers evaluated both Tl-SPECT and MIBI-SPECT individually. The interpretation criteria were graded as grade 1 (no abnormal increased uptake) to 5 (definitely increased uptake of a degree equal to or greater than that of normal salivary gland). Statistical analysis of the comparison of Tl-SPECT and MIBI-SPECT was performed. The interobserver difference was evaluated using the κ-coefficient. Quantitatively, T/N ratio (the ratio of the counts in the tumor divided by that in the normal nuchal muscles) and retention index were compared between Tl-SPECT and MIBI-SPECT.

Results

On both the early and delayed images, the grades of uptake of the tumor in Tl-SPECT were significantly higher than those in MIBI-SPECT by three observers. The grade of T1-uptake of the tumor on the delayed images was 5 for all observers (κ-coefficient =1); however, the κ-coefficient varied from 0.39 to 0.84 in early Tl-SPECT, and in early and delayed MIBI-SPECT. Statistical differences in T/N ratio were noted between early Tl-SPECT (2.87 ± 1.19) and MIBI-SPECT (2.48 ± 1.06), and between delayed Tl-SPECT (2.11 ± 0.70) and MIBI-SPECT ( 1.20 ± 0.48). The retention index of Tl-SPECT (0.81 ± 0.24) was significantly higher than that of MIBI-SPECT (0.52 ± 0.15).

Conclusions

The present study qualitatively and quantitatively showed that201T1 had higher accumulation in the tumor than99mTc-MIBI in both early and delayed images.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Fukumoto M. Single-photon agents for tumor imaging:201T1,99mTc-MIBI, and99mTc-tetrofosmin.Ann Nucl Med 2004; 18:79–95.

    Article  PubMed  CAS  Google Scholar 

  2. Berk F, Demir H, Aktolun C. Thallium-201 imaging in the assessment of tumor response to anti-tumor treatments.Q J Nucl Med 2003; 47:63–74.

    PubMed  CAS  Google Scholar 

  3. Mukherji SK, Gapany M, Phillips D, Neelon B, O’Brien S, McCartney W, et al. Thallium-201 single-photon emission CT versus CT for the detection of recurrent squamous cell carcinoma of the head and neck.AJNR 1999; 20:1215–1220.

    PubMed  CAS  Google Scholar 

  4. Tai CJ, Liang JA, Yang SN, Tsai MH, Lin CC, Kao CH. Detection of recurrent nasopharyngeal carcinomas with thallium-201 single-photon emission computed tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy.Head Neck 2003; 25:227–231.

    Article  PubMed  Google Scholar 

  5. Shiau YC, Liu FY, Huang WS, Yen RF, Kao CH. Using thallium-201 SPECT to detect recurrent or residual nasopharyngeal carcinoma after radiotherapy in patients with indeterminate CT findings.Head Neck 2003; 25:645–648.

    Article  PubMed  Google Scholar 

  6. Shiau YC, Tsai SC, Ho YJ, Kao CH. Comparison of technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography to detect recurrent or residual nasopharyngeal carcinomas after radiotherapy.Anticancer Res 2001; 21:2213–2218.

    PubMed  CAS  Google Scholar 

  7. Kao CH, Shiau YC, Shen YY, Yen RF. Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography.Cancer 2002; 94:1981–1986.

    Article  PubMed  Google Scholar 

  8. Nosotti M, Santambrogio L, Gasparini M, Baisi A, Bellaviti N, Rosso L. Role of99mTc-hexakis-2-methoxyisobutyl- isonitrile in the diagnosis and staging of lung cancer.Chest 2002; 122:1361–1364.

    Article  PubMed  Google Scholar 

  9. Tsai MH, Shiau YC, Tai CJ, Lin CC, Lee CC, Kao A. Detection of recurrent nasopharyngeal carcinomas with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy.Ann Otol Rhinol Laryngol 2003; 112:415–418.

    PubMed  Google Scholar 

  10. Kim SJ, Kim IJ, Bae YT, Kim YK, Kim DS. Incremental diagnostic value of quantitative analysis of double phase Tc-99m MIBI scintimammography for the detection of primary breast cancer additive to visual analysis.Breast Cancer Res Treat 2004; 83:129–138.

    Article  PubMed  Google Scholar 

  11. Fuster D, Vinolas N, Mallafre C, Pavia J, Martin F, Pons F. Tetrofosmin as predictor of tumour response.G J Nucl Med 2003; 47:58–62.

    CAS  Google Scholar 

  12. Jeune FPL, Dubois F, Perez S, Blond S, Steinling M. Technetium-99m sestamibi brain SPECT in the follow-up of glioma for evaluation of response to chemotherapy: first results.Eur J Nucl Med Mol Imaging 2004; 31:714–719.

    Article  CAS  Google Scholar 

  13. Sobin LH, Wittekind Ch.UICC international union against cancer. TNM classification of malignant tumours.6th ed. New York; Wiley-Liss, 2002.

    Google Scholar 

  14. Tomura N, Kobayashi M, Oyama Y, Satoh K, Kato K, Kusaka K, et al. Thallium-201 single photon emission computed tomography in the evaluation of therapeutic response for brain tumors.KAKU IGAKU (Jpn J Nucl Med) 1994; 31:951–956.

    CAS  Google Scholar 

  15. McGuirt WF, Greven K, Williams D 3rd, Keyes JW Jr, Watson N, Cappellari JO. PET scanning in head and neck oncology: a review.Head Neck 1998; 20:208–215.

    Article  PubMed  CAS  Google Scholar 

  16. Tomura N, Hirano H, Watanabe O, Hirano Y, Kato K, Sasaki K, et al. Comparison of thallium-201 and gallium-67 imaging in evaluation of head and neck tumors.J Comput Assist Tomogr 2000; 24:454–460.

    Article  PubMed  CAS  Google Scholar 

  17. Tomura N, Hirano H, Watanabe O, Kato K, Sasaki K, Watarai J, et al. Preliminary results with technetium-99m MIBI SPECT imaging in patients with brain tumors: correlation with histological and neuroradiological diagnosis and therapeutic response.Comput Med Imaging Graph 1997; 21:293–298.

    Article  PubMed  CAS  Google Scholar 

  18. Nishiyama Y, Yamamoto Y, Fukunaga K, Satoh K, Kunishio K, Ohkawa M. Comparison of99Tcm-MIBI with20lTl chloride SPET in patients with malignant brain tumours.Nucl Med Commun 2001; 22:631–639.

    Article  PubMed  CAS  Google Scholar 

  19. Yamamoto Y, Nishiyama Y, Toyama Y, Kunishio K, Satoh K, Ohkawa M.99mTc-MIBI and201Tl SPET in the detection of recurrent brain tumours after radiation therapy.Nucl Med Commun 2002; 23:1183–1190.

    Article  PubMed  CAS  Google Scholar 

  20. O’Tuama LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, et al. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison.J Nucl Med 1993; 34:1045–1051.

    PubMed  CAS  Google Scholar 

  21. Wang SJ, Hsu CY, Lin WY, Kao CH, Jan JS, Yeh SH. Comparison of Tl-201 and Tc-99m MIBI SPECT imaging in nasopharyngeal carcinoma.Clin Nucl Med 1995; 20:800–802.

    Article  PubMed  CAS  Google Scholar 

  22. Henze M, Mohammed A, Mier W, Rudat V, Dietz A, Nollert J, et al. Pretreatment evaluation of carcinomas of the hypopharynx and larynx withl8F-fluorodeoxyglucose,123I- α-methyl-L-tyrosine and99mTc-hexakis-2-methoxyiso- butylisonitrile.Eur J Nucl Med 2002; 29:324–330.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Akita University School of Medicine, 1-1-1, Hondo, 010-8543, Akita, JAPAN

    Noriaki Tomura, Osamu Watanabe, Satoshi Takahashi, Ikuo Sakuma, Takahiro Otani, Toshiaki Nishii & Jiro Watarai

Authors
  1. Noriaki Tomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Osamu Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoshi Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ikuo Sakuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takahiro Otani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Toshiaki Nishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jiro Watarai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noriaki Tomura.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tomura, N., Watanabe, O., Takahashi, S. et al. Comparison of201Tl-chloride SPECT with99mTc-MIBI SPECT in the depiction of malignant head and neck tumors. Ann Nucl Med 20, 107–114 (2006). https://doi.org/10.1007/BF02985622

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02985622

Key words

Search

Navigation