Annals of Nuclear Medicine

, Volume 20, Issue 9, pp 615–621 | Cite as

Transient ischemic dilation ratio (TID) correlates with HbA1C in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT

  • Alena Adamikova
  • Jiri Bakala
  • Jaromir Bernatek
  • Jaroslav Rybka
  • Stepan Svacina
Original Article



Abnormal values of the transient ischemic dilation ratio (TID) according to an exercise myocardial SPECT are linked to severe coronary artery disease. The authors investigated the relationship between TID and the levels of VCAM, ICAM, E-selectin, microalbuminuria, intima-media thickness and HbA1c of diabetic subjects.


We observed 38 subjects with diabetes type 2 (10 women, 28 men), of average age 56.08 ± 8.24 years, with no past history of cardiovascular disease. All subjects were examined using an exercise myocardial SPECT. Transient ischemic dilation, summed stress score (SSS), summed rest score (SRS) and stress total severity score (STSS) were determined to quantify myocardial ischemia.


The average IMT value was 1.05 ± 0.31 mm. The TID value was 1.02 ± 0.154, VCAM 795.24 ± 163.25 mg/l, ICAM 516.55 ± 164.07, E-selectin 63.82 ± 38.89, HbA1c 7.09 ± 1.68%, microalbuminuria 68.01 ± 55.21 mg/l. When ascertaining the relation of TID to the other factors we used Pearson’s correlation at the level of significance p < 0.05. We proved a statistically significant correlation between the value of TID and glycosylated hemoglobin HbA1c (p = 0.035); the other factors did not show any significant correlation.


Diabetes and its long term unsatisfactory compensation can be one of the factors which affect left ventricular transient ischemic dilation.

Key words

transient ischemic dilation glycosylated hemoglobin diabetes mellitus coronary artery disease 


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Copyright information

© Springer 2006

Authors and Affiliations

  • Alena Adamikova
    • 1
    • 4
  • Jiri Bakala
    • 2
  • Jaromir Bernatek
    • 2
  • Jaroslav Rybka
    • 1
  • Stepan Svacina
    • 3
  1. 1.Diabetes CenterWHO Collaborating Center for the Study of DiabetesCzech Republic
  2. 2.Department of Nuclear MedicineBata Regional HospitalZlínCzech Republic
  3. 3.First Faculty of Medicine, Charles UniversityPragueCzech Republic
  4. 4.Diabetes CenterWHO Collaborating Center, Bata HospitalZlínCzech Republic

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