Abstract
Objective
Abnormal values of the transient ischemic dilation ratio (TID) according to an exercise myocardial SPECT are linked to severe coronary artery disease. The authors investigated the relationship between TID and the levels of VCAM, ICAM, E-selectin, microalbuminuria, intima-media thickness and HbA1c of diabetic subjects.
Methods
We observed 38 subjects with diabetes type 2 (10 women, 28 men), of average age 56.08 ± 8.24 years, with no past history of cardiovascular disease. All subjects were examined using an exercise myocardial SPECT. Transient ischemic dilation, summed stress score (SSS), summed rest score (SRS) and stress total severity score (STSS) were determined to quantify myocardial ischemia.
Results
The average IMT value was 1.05 ± 0.31 mm. The TID value was 1.02 ± 0.154, VCAM 795.24 ± 163.25 mg/l, ICAM 516.55 ± 164.07, E-selectin 63.82 ± 38.89, HbA1c 7.09 ± 1.68%, microalbuminuria 68.01 ± 55.21 mg/l. When ascertaining the relation of TID to the other factors we used Pearson’s correlation at the level of significance p < 0.05. We proved a statistically significant correlation between the value of TID and glycosylated hemoglobin HbA1c (p = 0.035); the other factors did not show any significant correlation.
Conclusion
Diabetes and its long term unsatisfactory compensation can be one of the factors which affect left ventricular transient ischemic dilation.
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Adamikova, A., Bakala, J., Bernatek, J. et al. Transient ischemic dilation ratio (TID) correlates with HbA1C in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT. Ann Nucl Med 20, 615–621 (2006). https://doi.org/10.1007/BF02984659
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DOI: https://doi.org/10.1007/BF02984659