Annals of Nuclear Medicine

, Volume 19, Issue 3, pp 207–215 | Cite as

Three-dimensional registration of myocardial perfusion SPECT and CT coronary angiography

  • Hidenobu Nakajo
  • Shin-ichiro Kumita
  • Keiichi Cho
  • Tatsuo Kumazaki
Original Article



In this study, we describe a new technique for three-dimensional registration of CT coronary angiography (CTCA) and gated myocardial perfusion SPECT.


Twelve patients with known or suspected CAD who underwent CTCA and gated SPECT were enrolled retrospectively. Coronary arteries and their branches were traced using CTCA data manually and reconstructed in three-dimensions. Gated SPECT data were registered and mapped to a left ventricle binary model extracted from CTCA data using manual, rigid and nonrigid registration methods.


Three-dimensional reconstruction and volume visualization of both modalities were successfully achieved for all patients. All 3 registration methods gave better quality based on visual inspection, and nonrigid registration gave significantly better results than the other registration methods (p < 0.05). The cost function for three-dimensional registration using nonrigid registration (235.3 ± 13.9) was significantly better than those of manual and rigid registration (218.5 ± 15.3 and 223.7 ± 17.0, respectively). Inter-observer reproducibility error was within acceptable limits for all methods, and there were no significant difference among the methods.


This technique of image registration may assist the integration of information from gated SPECT and CTCA, and may have clinical application for the diagnosis of ischemic heart disease.

Key words

single photon emission computed tomography three-dimensional registration computed tomographic coronary angiography 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schroeder S, Kopp AF, Baumbach A, Kuettner A, Herdeg C, Rosenberger A, et al. Noninvasive detection of coronary lesions by multislice computed tomography: results of the new age pilot trial.Cathet Cardiovasc Intervent 2001; 53:352–358.CrossRefGoogle Scholar
  2. 2.
    Gerber TC, Kuzo RS, Lane GE, O’Brien PC, Karstaedt N, Morin RL, et al. Image quality in a standardized algorithm for minimally invasive coronary angiography with multislice spiral computed tomography.J Comput Assist Tomogr 2003; 27:62–69.PubMedCrossRefGoogle Scholar
  3. 3.
    Choudhury RP, Fuster V, Badimon JJ, Fisher EA, Fayad ZA. MRI and characterization of atherosclerotic plaque: emerging applications and molecular imaging.Arterioscler Thromb Vasc Biol 2002; 22:1065–1074.PubMedCrossRefGoogle Scholar
  4. 4.
    Kopp AF, Schroeder S, Baumbach A, Kuettner A, Georg C, Ohnesorge B, et al. Non-invasive characterisation of coronary lesion morphology and composition by multislice CT: first results in comparison with intracoronary ultrasound.Eur Radiol 200l; 11:1607–1611.CrossRefGoogle Scholar
  5. 5.
    Mahnken AH, Wildberger JE, Sinha AM, Dedden K, Stanzel S, Hoffmann R, et al. Value of 3D-volume rendering in the assessment of coronary arteries with retrospectively ECG-gated multislice spiral CT.Acta Radiol 2003; 44:302–309.PubMedCrossRefGoogle Scholar
  6. 6.
    Faber T, McColl R, Opperman R, Corbett J, Peshock R. Spatial and temporal registration of cardiac SPECT and MR images: methods and evaluation.Radiology 1991; 179:857–861.PubMedGoogle Scholar
  7. 7.
    Peifer JW, Ezquerra NF, Cooke CD, Mullick R, Klein L, Hyche ME, et al. Visualization of multimodality cardiac imagery.IEEE Trans Biomed Eng 1990; 37:744–756.PubMedCrossRefGoogle Scholar
  8. 8.
    Schindler TH, Magosaki N, Jeserich M, Oser U, Krause T, Fischer R, et al. Fusion imaging: combined visualization of 3D reconstructed coronary artery tree and 3D myocardial scintigraphic image in coronary artery disease.Int J Card Imaging 1999; 15:357–368.PubMedCrossRefGoogle Scholar
  9. 9.
    Sturm B, Kimerly A, Powell, Arthur ES, Richard DW. Registration of 3D CT angiography and cardiac MR images in coronary artery disease patients.Int J Card Imaging 2003; 19:281–293.CrossRefGoogle Scholar
  10. 10.
    Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American heart association.Circulation 2002; 105:539–542.PubMedCrossRefGoogle Scholar
  11. 11.
    Woods RP. Spatial transformation models. In:Handbook of medical imaging processing and analysis, Bankman IN (ed), San Diego; Academic Press, 2000: 465–497.CrossRefGoogle Scholar
  12. 12.
    Herk MV. Image registration using chamfer matching. In:Handbook of medical imaging processing and analysis, Bankman IN (ed), San Diego; Academic Press, 2000: 515–527.CrossRefGoogle Scholar
  13. 13.
    Barnden L, Kwiatek R, Lau Y, Hutton B, Thurfjell L, Pile K, et al. Validation of fully automatic brain SPET to MR co-registration.Eur J Nucl Med 2000; 27:147–154.PubMedCrossRefGoogle Scholar
  14. 14.
    Nakajo H, Kumita S, Mizumura S, Cho K, Kijima T, Kumazaki T, et al. Assessment of left ventricular contraction abnormalities with myocardial infarction using gated technetium-99m sestamibi SPECT: comparison of wall thickening and regional ejection fraction analysis for the detection of coronary artery stenosis.KAKU IGAKU (Jpn J Nucl Med) 1999; 36:435–443.Google Scholar
  15. 15.
    Sharir T, Berman DS, Waechter PB, Areeda J, Kavanagh PB, Gerlach J, et al. Quantitative analysis of regional motion and thickening by gated myocardial perfusion SPECT: normal heterogeneity and criteria for abnormality.J Nucl Med 2001; 42:1630–1638.PubMedGoogle Scholar
  16. 16.
    Schwartz JG, Johnson RB, Aepfelbacher FC, Paeker JA, Chen L, Azar RR, et al. Sensitivity, specificity and accuracy of stress SPECT myocardial perfusion imaging for detection of coronary artery disease in the distribution of first-order branch vessels, using an anatomical matching of angiographic and perfusion data.Nucl Med Commun 2003; 24:543–549.PubMedCrossRefGoogle Scholar
  17. 17.
    Biedenstein S, Schafers M, Stegger L, Kuweit T, Schober O. Three-dimensional contour detection of left ventricular myocardium using elastic surfaces.Eur J Nucl Med 1999; 26:201–207.PubMedCrossRefGoogle Scholar
  18. 18.
    Faber TL, Cooke CD, Peifer JW, Pettigrew RI, Vansant JP, Leyendecker JR, et al. Three-dimensional displays of left ventricular epicardial surface from standard cardiac SPECT perfusion quantification techniques.J Nucl Med 1995; 36:697–703.PubMedGoogle Scholar
  19. 19.
    Henri CJ, Peters TM. Three-dimensional reconstruction of vascular trees. Theory and methodology.Med Phys 1996; 23:197–204.PubMedCrossRefGoogle Scholar
  20. 20.
    Achenbach S, Daniel WG. Noninvasive coronary angiography—An acceptable alternative?N Eng J Med 2001; 345:1909–1910.CrossRefGoogle Scholar
  21. 21.
    Falk E, Shah PK, Fuster V. Coronary Plaque Disruption.Circulation 1995; 92:657–671.PubMedGoogle Scholar
  22. 22.
    Schroeder S, Kopp AF, Baumbach A, Meisner C, Kuettner A, Georg C, et al. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography.J Am Coll Cardiol 2001; 37:1430–1435.PubMedCrossRefGoogle Scholar
  23. 23.
    Germano G, Erel J, Lewin H, Kavanagh PB, Berman DS. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography.J Am Coll Cardiol 1997; 30:1360–1367.PubMedCrossRefGoogle Scholar
  24. 24.
    Kumita S, Cho K, Nakajo H, Toba M, Kijima T, Mizumura S, et al. Serial assessment of left ventricular function during dobutamine stress by means of electrocardiography-gated myocardial SPECT: combination with dual-isotope myocardial perfusion SPECT for detection of ischemic heart disease.J Nucl Cardiol 2001; 8:152–157.PubMedCrossRefGoogle Scholar
  25. 25.
    Choi J, Lee K, Kim S, Kim S, Kim B, Lee S, et al. Gating provides improved accuracy for differentiating artifacts from true lesions in equivocal fixed defects on technetium 99m tetrofosmin perfusion SPECT.J Nucl Cardiol 1998; 5:395–401.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Hidenobu Nakajo
    • 1
  • Shin-ichiro Kumita
    • 1
  • Keiichi Cho
    • 1
  • Tatsuo Kumazaki
    • 1
  1. 1.Department of Radiology, Center for Advanced Medical TechnologyNippon Medical SchoolTokyoJapan

Personalised recommendations