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Correlation between angiogenesis and reduction ratio measured using201Tl chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma

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Abstract

Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using201T1 single photon emission computed tomography (Tl SPECT) in oral cavity squamous cell carcinoma (SCC).Methods: Tl SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating microvessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using Tl SPECT (T/N at pre-an post-treatment, reduction ratio) and prognosis.Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence.Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of201Tl uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.

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Authors and Affiliations

  1. Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8549, Tokyo, Japan

    Aya Suzuki, Takashi Togawa & Ken Omura

  2. Divisions of Nuclear Medicine, USA

    Aya Suzuki, Junpei Kuyama & Tadaki Nakahara

  3. Surgical Pathology Center, USA

    Toshinao Takenouchi

  4. Radiation Oncology, Chiba Cancer Center, Japan

    Kazuo Hatano

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  1. Aya Suzuki
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  2. Takashi Togawa
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  7. Ken Omura
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Correspondence to Aya Suzuki.

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Suzuki, A., Togawa, T., Kuyama, J. et al. Correlation between angiogenesis and reduction ratio measured using201Tl chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma. Ann Nucl Med 18, 599–607 (2004). https://doi.org/10.1007/BF02984582

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  • DOI: https://doi.org/10.1007/BF02984582

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