Breast Cancer

, Volume 11, Issue 3, pp 313–317 | Cite as

Pathological fracture of the femur ten years after successful radiation therapy for metastatic breast cancer

  • Hiroshi Hatano
  • Tetsuro Morita
  • Hiroto Kobayashi
  • Takui Ito
  • Hiroyuki Segawa
  • Mari Saito
Case Report


We describe a case involving a 75-year-old woman presenting with a femur fracture 10 years after radiation therapy for metastatic breast cancer, which developed in the right femur. The lesion showed complete response with bone healing following radiation therapy; however, the patient sustained a femur fracture ten years later. Histological examination of the specimens obtained from the lesion revealed features of radiation osteonecrosis, but there was no histological evidence of tumor. To our knowledge, there has been no reported case of pathological fracture ten years after radiation therapy from radiation osteonecrosis rather than progression of the metastatic lesion. Late complications of radiation therapy should be considered with care, even when metastatic lesions demonstrate complete response to treatment.

Key words

Breast cancer Bone metastasis Pathological fracture Femur Radiation osteonecrosis 


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Copyright information

© The Japanese Breast Cancer Society 2004

Authors and Affiliations

  • Hiroshi Hatano
    • 1
  • Tetsuro Morita
    • 1
  • Hiroto Kobayashi
    • 1
  • Takui Ito
    • 1
  • Hiroyuki Segawa
    • 1
  • Mari Saito
    • 2
  1. 1.Department of Orthopedic SurgeryNiigata Cancer Center HospitalNiigata CityJapan
  2. 2.Department of RadiologyNiigata Cancer Center HospitalJapan

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