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Journal of Genetics

, Volume 55, Issue 3, pp 570–584 | Cite as

The morphology and development of ragged— a mutant affecting the skin and hair of the house mouse II. Genetics, Embryology and Gross Juvenile Morphology

With plate 23 and one text-figure
  • John Slee
Article

Summary

  1. 1.

    Ra + mice were normally viable. In the original stock allRaRa mice died before birth or at birth, showing generalized oedema. Later a selected substock provided some viableRaRa mice, although the mortality rate both before and after birth was still above normal.

     
  1. 2. (a)

    Embryological studies in the unselected stock proved that about 40% ofRaRa mice died as embryos.

     
  2. (b)

    RaRa embryos exhibited varying grades of oedema; those embryos with high-grade oedema were probably selectively liable to die.

     
  3. (c)

    Ra+ embryos could be classified from 16 1/2 days’ gestation by the retardation of sinus hair growth.RaRa embryos were identified from 13 1/2 days onwards by the occurrence of oedema and retardation of the development of sinus hairs and their follicles.

     
  1. 3.

    Phenotypic continuity for the + +,Ra+ andRaRa genotypes was observed from their identification as embryos until after birth. NeonatalRa + mice had shorter than normal sinus hairs, and the pre-weanmg development of pelage hairs was slower than normal. All neonatalRaRa mice showed very retarded sinus hair growth; in viableRaRa mice there was no visible pelage hair growth, at least up to the age of 2 weeks.RaRa mice were significantly heavier than normal at birth, but the survivors were significantly lighter than normal at weaning.

     
  2. 4.

    There were no gross anomalies in the blood ofRa + orRaRa mice.

     
  3. 5.

    After discussion it was concluded that:

     
  1. (a)

    Hair-growth retardation was a fundamental aspect of the ragged syndrome.

     
  2. (b)

    Among the many possible causes of oedema inRaRa mice, the two most likely were: (i) partial heart failure, or (ii) endocrine abnormality.

     
  3. (c)

    The cause of death, when it occurred inRaRa mice, was probably heart failure and/or pulmonary oedema.

     

Keywords

Hair Follicle Neonatal Mouse Generalize Oedema Ragged Gene Dead Embryo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Indian Academy of Sciences 1957

Authors and Affiliations

  • John Slee
    • 1
  1. 1.Institute of Animal GeneticsEdinburgh UniversityEdinburgh

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