Abstract
Objective: To study the factors affecting post-operative staging and survival in non-small cell lung cancer (NSCLC) patients based on the revised TNM staging system adopted by the UICC in 1977. Methods: Data were collected from 1757 consecutively operated NSCLC patients, including those receiving complete tumor excision, tumor debulking and exploratory thoractomy from April 1969 through Dec. 1993. the end point of follow-up was Nov. 30, 1998. Cumulative survival and its influencing factors were analyzed by Kaplan-Meier and Cox model of SPSS software. Results: In this series, 30 patients (1.7%) were lost from follow-up. The 5-year cumulative survival was 88.0% for patients in stage I A, and 53.9% in stage IB, 33.5% in stage II, 14.7% in stage III A, 5.5% in stage IIIB and 7.0% in stage IV. The overall 5-year survival rate was 28.2%. The 5-year survivals were 39.8%, 14.4% and 4.2% in patients treated with completely tumor resection, tumor debulking and explorative thoractomy, respectively. The 10-year survival rate was 31.4%, 9.5% and 0, respectively. Factors affecting long-term cumulative survival, in the order of decreasing significance, were the type of operation, lymph node status, staging, size and pathological type of the primary tumor. Conclusion: the revised staging system for NSCLC is superior to that used since 1986 as far as the end results of treatment in patients in different stage and the staging specificity are concerned. The T3N1M0 classification and the definition of Ml need to be further studied.
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References
UICC. TNM Classification of Malignant Tumors. 5th ed. New York: Wiley-Liss, 1997; 93.
AJCC. AJCC Cancer Staging manual. 5th ed. Philadelphia: Lippincott-Raven, 1997; 91.
Mountain CF. A new international staging system for lung cancer. Chest 1986; 89: 225s.
Ginsberg RJ, Vokes EE, Raben A. Non-Small Cell Lung Cancer. In: Devita VT, Hellman JS, Rosenberg SA, eds. Cancer principles ⇐p; Practice of Oncology. 5th ed. New York: Lippincott-Raven Publishers, 1997; 887.
Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997; 111:1710.
Urschel JD, Usschel DM, Anderson TM, et al. Prognostic implications of pulmonary satellite nodules: are the 1997 stging revisions appropriate? Lung Cancer 1998; 21: 83.
Motta G. Commentary. Lung Cancer 1998; 21: 89.
Shimazu N, Ando a, Date H, et al. Prognosis of undetected intrapulmonary metastases in resected lung cancer. Cancer 1993; 71: 3868.
Fukuse T, Hirata T, Tanaka F, et al. prognosis of ispilateral intrapulmonary metastases in resedcted non small cell lung cancer. Eur J Cardio-Thoracic Surg 1997; 12: 218.
Yoshino I, Nakanishi R, Osaki T, et al. Postoperative prognosis in patients with non small cell lung cancer with synchronous ipsilateral intrapulmonary metastsis. Ann Thorac surg 1997; 64: 809.
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This work was supported by a grant from The Science and Technology Committee of Guangdong Province, China (No. 93 - 069 - 073).
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Wu, Yl., Huang, Zf., Wang, Sy. et al. Post-operative staging and survival based on the revised tnm staging system for non-small cell lung cancer. Chin J Cancer Res 12, 278–281 (2000). https://doi.org/10.1007/BF02983506
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DOI: https://doi.org/10.1007/BF02983506