The developmental origins of sarcopenia

  • A. A. Sayer
  • H. Syddall
  • H. Martin
  • H. Patel
  • D. Baylis
  • C. Cooper


Birth Weight Grip Strength Developmental Origin Normal Birth Weight Developmental Plasticity 
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  1. 1.
    Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med 2001;137:231–43.PubMedCrossRefGoogle Scholar
  2. 2.
    Sayer AA, Syddall HE, Martin HJ, Dennison EM, Roberts HC, Cooper C. Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study. Age Ageing 2006;35:409–15.PubMedCrossRefGoogle Scholar
  3. 3.
    Sayer AA, Dennison EM, Syddall HE, Gilbody HJ, Phillips DI, Cooper C. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care 2005;28:2541–2.PubMedCrossRefGoogle Scholar
  4. 4.
    Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol. 2007;36:228–35.PubMedCrossRefGoogle Scholar
  5. 5.
    Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr.Soc. 2004;52:80–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Marcell TJ. Sarcopenia: causes, consequences, and preventions. J.Gerontol.A Biol.Sci.Med.Sci. 2003;58:M911-M916.PubMedGoogle Scholar
  7. 7.
    Roubenoff R. Sarcopenia and its implications for the elderly. Eur J Clin Nutr 2000;54:S40-S47.Google Scholar
  8. 8.
    Arden NK,. Spector TD. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res 1997;12:2076–81.PubMedCrossRefGoogle Scholar
  9. 9.
    Vincent KR, Braith RW, Feldman RA, Magyari PM, Cutler RB, Persin SA et al. Resistance exercise and physical performance in adults aged 60 to 83. J Am Geriatr.Soc. 2002;50:1100–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Skelton DA, Young A, Greig CA, Malbut KE. Effects of resistance training on strength, power, and selected functional abilities of women aged 75 and older. J Am Geriatr.Soc 1995;43:1081–7.PubMedGoogle Scholar
  11. 11.
    Bateson P, Barker D, Clutton-Brock T, Deb D, D’Udine B, Foley RA et al. Developmental plasticity and human health. Nature 2004;430:419–21.PubMedCrossRefGoogle Scholar
  12. 12.
    Lucas A. Programming by early nutrition in man. In Bock GR, Whelan J, eds. The childhood environment and adult disease. Ciba Foundation Symposium 156, pp 38–50. Chichester: John Wiley, 1991.CrossRefGoogle Scholar
  13. 13.
    West-Eberhard MJ. Phenotypic plasticity and the origins of diversity. Ann Rev Ecol Syst 1989;20:249–78.CrossRefGoogle Scholar
  14. 14.
    Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science 2004;305:1733–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Burdge GC, Hanson MA, Slater-Jefferies JL, Lillycrop KA. Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br.J Nutr. 2007;1-11.Google Scholar
  16. 16.
    Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005;135:1382–6.PubMedGoogle Scholar
  17. 17.
    Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, Burdge GC. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARalpha promoter of the offspring. Br.J Nutr. 2008;1-5.Google Scholar
  18. 18.
    Costello PM, Rowlerson A, Astaman NA, Anthony F, Aihie Sayer A, Cooper C et al. Peri-implanatation and late gestation maternal underautrition differentially affect fetal sheep skeletal muscle development. J Physiol 2008;In press.Google Scholar
  19. 19.
    Greenwood PL, Hunt AS, Hermanson JW, Bell AW. Effects of birth weight and postnatal nutrition on neonatal sheep: II. Skeletal muscle growth and development. J Anim Sci 2000;78:50–61.PubMedGoogle Scholar
  20. 20.
    Dwyer CM, Stickland NC, Fletcher JM. The influence of maternal nutrition on muscle fiber number development in the porcine fetus and on subsequent postnatal growth. J Anim Sci 1994;72:911–7.PubMedGoogle Scholar
  21. 21.
    Dwyer CM, Madgwick AJ, Ward SS, Stickland NC. Effect of maternal undernutrition in early gestation on the development of fetal myofibres in the guinea-pig. Reprod Fertil Dev 1995;7:1285–92.PubMedCrossRefGoogle Scholar
  22. 22.
    Wilson SJ, Ross JJ, Harris AJ. A critical period for formation of secondary myotubes defined by prenatal undernourishment in rats. Development 1988;102:815–21.PubMedGoogle Scholar
  23. 23.
    Prakash YS, Fournier M, Sieck GC. Effects of prenatal underautrition on developing rat diaphragm. J Appl.Physiol 1993;75:1044–52.PubMedGoogle Scholar
  24. 24.
    Pond WG, Yen JT, Mersmann HJ, Maurer RR. Reduced mature size in progeny of swine severely restricted in protein intake during pregnancy. Growth Dev.Aging 1990;54:77–84.PubMedGoogle Scholar
  25. 25.
    Aihie Sayer A, Cooper C. Early undernutrition: good or bad for longevity? In Watson RR, ed. Handbook of nutrition in the aged., pp 97–106. Boca Raton: CRC Press Inc, 2000.Google Scholar
  26. 26.
    Dauncey MJ, Gilmour RS. Regulatory factors in the control of muscle development. Proc Nutr Soc 1996;55:543–59.PubMedCrossRefGoogle Scholar
  27. 27.
    Maltin CA, Delday MI, Sinclair KD, Steven J, Sneddon AA. Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle. Reproduction 2001;122:359–74.PubMedCrossRefGoogle Scholar
  28. 28.
    Bailey P, Holowacz T, Lassar AB. The origin of skeletal muscle stem cells in the embryo and the adult. Curr Opin Cell Biol 2001;13:679–89.PubMedCrossRefGoogle Scholar
  29. 29.
    Stewart CE. The physiology of stem cells: potential for the elderly patient. J MusculoskeletNeuronal. Interact. 2004;4:179–83.Google Scholar
  30. 30.
    Sayer AA, Cooper C, Evans JR, Rauf A, Wormald RP, Osmond C et al. Are rates of ageing determined in utero? Age Ageing 1998;27:579–83.PubMedCrossRefGoogle Scholar
  31. 31.
    Sayer AA, Syddall HE, Gilbody HJ, Dennison EM, Cooper C. Does sarcopenia originate in early life? Findings from the Hertfordshire Cohort Study. J Gerontol 2004;59A:930–4.Google Scholar
  32. 32.
    Kuh D, Bassey J, Hardy R, Aihie Sayer A, Wadsworth M, Cooper C. Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol. 2002;156:627–33.PubMedCrossRefGoogle Scholar
  33. 33.
    Inskip HM, Godfrey KM, Martin HJ, Simmonds SJ, Cooper C, Aihie Sayer A. Size at birth and its relation to muscle strength in young adult women. J Int Med 2007;In press.Google Scholar
  34. 34.
    Wadsworth M, Kuh D, Richards M, Hardy R. Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development). Int.J Epidemiol. 2006;35:49–54.PubMedCrossRefGoogle Scholar
  35. 35.
    Kuh D, Hardy R, Butterworth S, Okell L, Wadsworth M, Cooper C et al. Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol.A Biol.Sci.Med Sci. 2006;61:702–6.PubMedGoogle Scholar
  36. 36.
    Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C et al. Birth weight, weight at one year and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr 2004;80:199–203.PubMedGoogle Scholar
  37. 37.
    Phillips DIW. Relation of fetal growth to adult muscle mass and glucose tolerance. Diab Med 1995;12:686–90.CrossRefGoogle Scholar
  38. 38.
    Gale CR, Martyn CN, Kellingray S, Eastell R, Cooper C. Intrauterine programming of adult body composition. J Clin Endocrinol Metab 2001;86:267–72.PubMedCrossRefGoogle Scholar
  39. 39.
    Yliharsila H, Kajantie E, Osmond C, Forsen T, Barker DJ, Eriksson JG. Birth size, adult body composition and muscle strength in later life. Int J Obes.(Lond) 2007; 31(9): 1392–1399CrossRefGoogle Scholar
  40. 40.
    Hediger ML, Overpeck MD, Kuczmarski RJ, McGlynn A, Maurer KR, Davis WW. Muscularity and fatness of infants and young children bora small- or large-for-gestational-age. Pediatrics 1998;102:E60.PubMedCrossRefGoogle Scholar
  41. 41.
    Singhal A, Wells J, Cole TJ, Fewtrell M, Lucas A. Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease? Am J Clin Nutr 2003;77:726–30.PubMedGoogle Scholar
  42. 42.
    Kahn HS, Narayan KM, Williamson DF, Valdez R. Relation of birth weight to lean and fat thigh tissue in young men. Int J Obes Relat Metab Disord 2000;24:667–72.PubMedCrossRefGoogle Scholar
  43. 43.
    Systematic reviews in health care. BMJ Books, 2001.Google Scholar
  44. 44.
    Inskip HM, Godfrey KM, Robinson SM, Law CM, Barker DJ, Cooper C. Cohort profile: The Southampton Women’s Survey. Int.J Epidemiol. 2005.Google Scholar
  45. 45.
    Harvey NC, Poole JR, Javaid MK, Dennison EM, Robinson S, Inskip HM et al. Parental determinants of neonatal body composition. J Clin Endocrinol Metab 2007;92:523–6.PubMedCrossRefGoogle Scholar
  46. 46.
    Thompson CH, Sanderson AL, Sandeman D, Stein C, Borthwick A, Radda GK et al. Fetal growth and insulin resistance in adult life: role of skeletal muscle morphology. Clin Sci (Colch) 1997;92:291–6.Google Scholar
  47. 47.
    Jensen CB, Storgaard H, Madsbad S, Richter EA, Vaag AA. Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight. J Clin Endocrinol Metab 2007;92:1530–4.PubMedCrossRefGoogle Scholar
  48. 48.
    Aihie Sayer A, Cooper C. Aging, sarcopenia and the life course. Rev Clin Gerontol 2007;16;265–274.Google Scholar
  49. 49.
    Singh GR,. Sayers SM. Birth weight, current body composition and grip strength in an aboriginal birth cohort. Early Hum Dev 2006;S156.Google Scholar
  50. 50.
    Saigal S, Stoskopf B, Boyle M, Paneth N, Pinelli J, Streiner D et al. Comparison of current health, functional limitations, and health care use of young adults who were born with extremely low birth weight and normal birth weight. Pediatrics 2007;119:e562-e573.PubMedCrossRefGoogle Scholar
  51. 51.
    Rogers M, Fay TB, Whitfield MF, Tomlinson J, Grunau RE. Aerobic capacity, strength, flexibility, and activity level in unimpaired extremely low birth weight (<or=800 g) survivors at 17 years of age compared with term-born control subjects. Pediatrics 2005;116:e58-e65.PubMedCrossRefGoogle Scholar
  52. 52.
    Martorell R, Ramakrishnan U, Schroeder DG, Melgar P, Neufeld L. Intrauterine growth retardation, body size, body composition and physical performance in adolescence. Eur.J Clin Nutr. 1998;52 Suppl 1:S43-S52.PubMedGoogle Scholar
  53. 53.
    Ford GW, Kitchen WH, Doyle LW. Muscular strength at 5 years of children with a birthweight under 1500 g. AustPaediatr.J 1988;24:295–6.Google Scholar

Copyright information

© Springer-Verlag France and Serdi Éditions 2008

Authors and Affiliations

  • A. A. Sayer
    • 1
  • H. Syddall
    • 1
  • H. Martin
    • 1
  • H. Patel
    • 1
  • D. Baylis
    • 1
  • C. Cooper
    • 1
  1. 1.MRC Epidemiology Resource CentreUniversity of Southampton, Southampton General HospitalSouthampton

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