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The Journal of Nutrition Health and Aging

, Volume 12, Issue 6, pp 355–364 | Cite as

Nutrition and aging. The Carla workshop

  • G. Abellan van Kan
  • G. Gambassi
  • L. C. P. G. M. de Groot
  • S. Andrieu
  • T. Cederholm
  • E. Andre
  • J. -R. Caudere
  • J. -R. Bonjour
  • P. Ritz
  • A. Salva
  • A. Sinclair
  • B. Vellas
Nutrition

Keywords

Fracture Risk Homocysteine Cognitive Decline Strontium Ranelate Frailty Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Haveman-Nies A, de Groot LP, Burema J, Cruz JA et al. Dietary quality and lifestyle factors in relation to 10-year mortality in older Europeans: the SENECA study. Am J Epidemiol 2002;156(10): 962–8PubMedGoogle Scholar
  2. 2.
    Knoops KT, de Groot LC, Kromhout D et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 2004;292(12): 1433–9PubMedGoogle Scholar
  3. 3.
    Van der Wielen RP, Löwik MR, van den Berg H et al. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995;346: 207–210PubMedGoogle Scholar
  4. 4.
    Prentice A. Diet, nutrition and the prevention of osteoporosis. Public Health Nutr 2004;7: 227–243PubMedGoogle Scholar
  5. 5.
    Boonen S, Vanderschueren D, Haentjens P, and Lips P. Calcium and vitamin D in the prevention and treatment of osteoporosis — a clinical update. J Intern Med 2006; 259(6): 539–552PubMedGoogle Scholar
  6. 6.
    Luchsinger JA, Mayeux R. Dietary factors and Alzheimer’s disease. Lancet Neurol 2004;3(10): 579–587PubMedGoogle Scholar
  7. 7.
    Gillette Guyonnet S, Abellan Van Kan G, Andrieu S et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007; 11(2): 132–152Google Scholar
  8. 8.
    Venning G. Recent developments in vitamin D deficiency and muscle weakness among elderly people. BMJ 2005;330: 524–526PubMedGoogle Scholar
  9. 9.
    Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005; 293(18): 2257–2264PubMedGoogle Scholar
  10. 10.
    Boonen S, Crepaldi G. Reducing fracture risk in the oldest old: aging and the effect of pharmaceutical interventions in osteoporosis. Aging Clin Exp Res 2007; 19(1): 1–3PubMedGoogle Scholar
  11. 11.
    Cranney A, Horsley T, O’Donnell S, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess 2007;(158): 1–235Google Scholar
  12. 12.
    van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350(20): 2033–2041PubMedGoogle Scholar
  13. 13.
    McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004; 350(20): 2042–2049PubMedGoogle Scholar
  14. 14.
    Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, et al. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005;20(6): 921–929PubMedGoogle Scholar
  15. 15.
    Sato Y, Honda Y, Iwamoto J, et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA. 2005; 293(9): 1082–1088PubMedGoogle Scholar
  16. 16.
    Raman G, Tatsioni A, Chung M, et al. Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function. J Nutr 2007; 137(7): 1789–1794PubMedGoogle Scholar
  17. 17.
    Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84(2): 361–370PubMedGoogle Scholar
  18. 18.
    Durga J, van Boxtel MP, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369(9557): 208–216PubMedGoogle Scholar
  19. 19.
    Morley JE. Orexigenic and anabolic agents. Clin Geriatr Med 2002; 18(4): 853–866PubMedGoogle Scholar
  20. 20.
    Morley JE. Pathophysiology of anorexia. Clin Geriatr Med 2002; 18(4): 661–673PubMedGoogle Scholar
  21. 21.
    Roberts SB, Fuss P, Heyman MB, et al. Control of food intake in older men. JAMA 1994; 272(20): 1601–1606PubMedGoogle Scholar
  22. 22.
    Dangour AD, Uauy R. Nutrition challenges for the twenty-first century. Br J Nutr 2006; 96 Suppl 1: S2–7PubMedGoogle Scholar
  23. 23.
    Vellas B, Andrieu S, Sampaio C, Wilcock G. Disease-modifying trials in Alzheimer’s disease: a European task force consensus. Lancet Neurol. 2007;6(1): 56–62PubMedGoogle Scholar
  24. 24.
    Fried LP, Tangen CM, Walston J, Newman AB, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3): 146–156Google Scholar
  25. 25.
    Roubenoff R. Sarcopenia: effects on body composition and function. J Gerontol A Biol Sci Med Sci 2003;58(11): 1012–1017PubMedGoogle Scholar
  26. 26.
    Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J Appl Physiol. 2000 Jul;89(1): 81–8PubMedGoogle Scholar
  27. 27.
    Frontera WR, Hughes VA, Fielding RA, et al. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol. 2000;88(4): 1321–1326PubMedGoogle Scholar
  28. 28.
    Greig CA, Botella J, Young A. The quadriceps strength of healthy elderly people remeasured after eight years. Muscle Nerve 1993;16(1): 6–10PubMedGoogle Scholar
  29. 29.
    Morley JE, Baumgartner RN, Roubenoff R, et al. Sarcopenia. J Lab Clin Med 2001;137(4): 231–243PubMedGoogle Scholar
  30. 30.
    Newman AB, Kupelian V, Visser M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 2003; 51(11): 1602–1609PubMedGoogle Scholar
  31. 31.
    Janssen I, Baumgartner RN, Ross R, et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004;159(4): 413–421PubMedGoogle Scholar
  32. 32.
    Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147(8): 755–763PubMedGoogle Scholar
  33. 33.
    Short KR, Nair KS. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care. 2000;3(1): 39–44PubMedGoogle Scholar
  34. 34.
    Baumgartner RN. Body composition in healthy aging. Ann N Y Acad Sci 2000;904: 437–448PubMedCrossRefGoogle Scholar
  35. 35.
    Blaum CS, Xue QL, Michelon E, et al. The association between obesity and the frailty syndrome in older women: the Women’s Health and Aging Studies. J Am Geriatr Soc 2005;53(6): 927–934PubMedGoogle Scholar
  36. 36.
    Villareal DT, Banks M, Sinacore DR, Siener C, Klein S. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med 2006; 166(8): 860–866PubMedGoogle Scholar
  37. 37.
    World Cancer Research Fund / American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. Washington DC: AICR, 2007Google Scholar
  38. 38.
    Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hoffmann A, Witteman JC et al. Diet and risk of dementia: Does fat matter? Neurology 2002; 59: 1915–1921PubMedCrossRefGoogle Scholar
  39. 39.
    Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Annals of Neurology 1997b; 42(5): 776–782PubMedGoogle Scholar
  40. 40.
    Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 2004; 62: 1573–1579PubMedGoogle Scholar
  41. 41.
    Morris MC, Evans DA, Bienias JL, et al. Dietary fats and the risk of incident Alzheimer’s disease. Arch Neurol 2003; 60: 194–200PubMedGoogle Scholar
  42. 42.
    Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S. Fish, meat, and risk of dementia: cohort study. BMJ 2002; 325(7370): 932–933PubMedGoogle Scholar
  43. 43.
    Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 2005; 62(12): 1849–1853PubMedGoogle Scholar
  44. 44.
    Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer’s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimer’s &Dementia 2005;11–18Google Scholar
  45. 45.
    Morris MC, Evans DA, Schneider JA, Tangney CC, Bienias, JL, Aggarwal NT. Dietary folate and vitamins B12 and B6 not associated with incident Alzheimer’s disease. Journal of Alzheimer’s Disease 2006;435–443Google Scholar
  46. 46.
    Seshadri S, Beiser A, Selhub J, Jacques PF et al. Plasma homocysteine as a risk factor dementia and Alzheimer’s disease. NEJM. 2002;346: 476–483PubMedGoogle Scholar
  47. 47.
    Ravaglia G, Forti P, Maioli F et al. Homocysteine and folate as risk factors for dementia and Alzheimer’s disease. Am J Clin Nutr. 2005;82: 636–643PubMedGoogle Scholar
  48. 48.
    Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer’s disease. Neurology. 2001;56(9): 1188–1194PubMedGoogle Scholar
  49. 49.
    Luchsinger JA, Tang MX, Shea S, Miller J, Green R, Mayeux R. Plasma homocysteine levels and risk of Alzheimer disease. Neurology. 2004;62(11): 1972–1976PubMedGoogle Scholar
  50. 50.
    Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT et al. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr. 2005; 81(2): 508–514PubMedGoogle Scholar
  51. 51.
    Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Vitamin E and Cognitive Decline. Arch Neurol. 2002; 59: 1125–1132PubMedGoogle Scholar
  52. 52.
    Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002; 287, 24: 3223–3229PubMedGoogle Scholar
  53. 53.
    Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer’s disease in a biracial community study. JAMA. 2002; 287: 3230–3237PubMedGoogle Scholar
  54. 54.
    Commenges D, Scotet V, Renuad S, et al. Intake of flavinoids and risk of dementia. Eur J Epidemiol. 2000; 16: 357–363PubMedGoogle Scholar
  55. 55.
    Laurin D, Masaki KH, Foley DJ, White LR, Launer LJ. Midlife dietary intake of antioxidants and risk of late-life incident dementia. The Honolulu-Asia Aging Study. Am J Epidemiol. 2004; 159: 959–967PubMedGoogle Scholar
  56. 56.
    Luchsinger JA, Tang MX, Shea S., Mayeux R. Antioxidant vitamin intake and risk of Alzheimer’s disease. Arch Neurol. 2003;60: 203–208PubMedGoogle Scholar
  57. 57.
    Maxwell CJ, Hicks MS, Hogan DB, Basran J, Ebly EM. Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement Geriatr Cogn Disor. 2005;20: 45–51Google Scholar
  58. 58.
    Masaki KH, Losonczy KG, Ismirlian G et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. 2000;54: 1265–1272PubMedGoogle Scholar
  59. 59.
    Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr. 2003;77: 975–984PubMedGoogle Scholar
  60. 60.
    Gray SL, Hanlon JT, Landerman LR, Artz M, Schmader KE, Fillenbaum GG. Is antioxydant use protective of cognitive function in the community-dwelling elderly? Am J Geriatr Pharmacother. 2003; 1: 3–10PubMedGoogle Scholar
  61. 61.
    Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol. 2004;61, 1: 82–88PubMedGoogle Scholar
  62. 62.
    Elmstahl S, Persson M, Andren M, Blabolil V. Malnutrition in geriatric patients: a neglected problem? J Adv Nurs. 1997; 26(5): 851–855PubMedGoogle Scholar
  63. 63.
    Sempos CT, Johnson NE, Elmer PJ, Allington JK, Matthews ME. A dietary survey of 14 Wisconsin nursing homes. J Am Diet Assoc. 1982;81(1): 35–40PubMedGoogle Scholar
  64. 64.
    Suominen N et al. Malnutrition and associated factors among aged residents in all nursing homes in Helsinki. Eur J Clin Nutr. 2005;59(4): 578–583PubMedGoogle Scholar
  65. 65.
    Zuliani G, Romagnoni F, Volpato S, et al. Nutritional parameters, body composition, and progression of disability in older disabled residents living in nursing homes. J Gerontol A Biol Sci Med Sci. 2001;56(4): 212–216Google Scholar
  66. 66.
    Amelia EJ. Mealtime difficulties. In: Mezey M, Fulmer T, Abraham I, Zwicker DA, editor(s). Geriatric nursing protocols for best practice. 2nd ed. New York (NY): Springer Publishing Company, Inc.; 2003. p. 66–82.Google Scholar
  67. 67.
    Blaum CS, Fries BE, Fiatarone MA. Factors associated with low body mass index and weight loss in nursing home residents. J Gerontol A Biol Sci Med Sci. 1995;50(3): 162–168Google Scholar
  68. 68.
    Corbett CF, Crogan NL, Short RA. Using the minimum data set to predict weight loss in nursing home residents. Appl Nurs Res. 2002; 15(4): 249–253PubMedGoogle Scholar
  69. 69.
    Persson M, Elmstahl S, Blabolil V. The reproducibility of a new dietary record routine in geriatric patients. Clin Nutr. 2002;21: 15–25PubMedGoogle Scholar
  70. 70.
    Vellas B, Villars H, Abellan G, Soto ME, et al. Overview of the MNA-Its history and challenges. J Nutr Health Aging. 2006; 10(6): 456–463PubMedGoogle Scholar
  71. 71.
    Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev. 2005; 18(2): CD003288Google Scholar
  72. 72.
    Koretz RL, Avenell A, Lipman TO, Braunschweig CL, Milne AC. Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials. Am J Gastroenterol 2007;102(2): 412–429PubMedGoogle Scholar
  73. 73.
    Fietkau R, Riepl M, Kettner H, Hinke A, Sauer R. Supportive use of megestrol acetate in patients with head and neck cancer during radio(chemo)therapy. Eur J Cancer 1997;33(1): 75–79PubMedGoogle Scholar
  74. 74.
    Reuben DB, Hirsch SH, Zhon K, Greendale GA. The Effects of Megestrol Acetate Suspension for Elderly Patients with Reduced Appetite After Hospitalization: A Phase II Randomized Clinical Trial. J Am Geriatr Soc. 2005;53(6): 970–975PubMedGoogle Scholar
  75. 75.
    Simmons SF, Walker KA, Osterweil D. The effect of megestrol acetate on oral food and fluid intake in nursing home residents: a pilot study. Am Med Dir Assoc. 2005;6(3 Suppl): S5-S11Google Scholar
  76. 76.
    World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 1994. Report of a WHO study group. WHO Technical Report Series; No 843Google Scholar
  77. 77.
    Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992;2: 285–289PubMedGoogle Scholar
  78. 78.
    Compston & Rosen: Fast Facts: Osteoporosis, Health Press 2006Google Scholar
  79. 79.
    Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002; 288(3): 321–333PubMedGoogle Scholar
  80. 80.
    Udell JA, Fischer MA, Brookhart MA, Solomon DH, Choudhry NK. Effect of the Women’s Health Initiative on osteoporosis therapy and expenditure in Medicaid. J Bone Miner Res. 2006;21(5): 765–771PubMedGoogle Scholar
  81. 81.
    De Laet C, Kanis JA, Odén A, et al. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int. 2005; 16(11): 1330–1338PubMedGoogle Scholar
  82. 82.
    Delmi, Rapin, Bengoa, Delmas, Vasey, Bonjour. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet. 1990; 337: 1013–1016Google Scholar
  83. 83.
    Tkatch, Rapin, Rizzoli, Slosman, Nydegger, Vasey, Bonjour. Benefits of oral protein supplementation with fracture of the proximal femur. J Am Col. Nutr. 1992; 11: 519–525Google Scholar
  84. 84.
    Geinoz, Rapin, Rizzoli, Kraemer, Buchs, Slosman, Michel, Bonjour. Relationship between bone mineral density and dietary intakes in the elderly. Osteoporos Int. 1993: 242–248Google Scholar
  85. 85.
    Schürch MA, Rizzoli R, Slosman D, et al. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998;128(10): 801–809PubMedGoogle Scholar
  86. 86.
    Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP. Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 2000; 15: 2504–2512PubMedGoogle Scholar
  87. 87.
    Munger RG, Cerhan JR, Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr 1999;69: 147–152PubMedGoogle Scholar
  88. 88.
    Kerstetter JE, O’Brien KO, Insogna KL. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. Am J Clin Nutr. 2003;78: 584S-592SPubMedGoogle Scholar
  89. 89.
    Bonjour JP. Dietary protein: an essential nutrient for bone health. J Am Coll Nutr. 2005;24: 526S-36SPubMedGoogle Scholar
  90. 90.
    Kyle UG, Genton L, Slosman DO, Pichard C. Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years. Nutrition. 2001; 17(7-8): 534–541PubMedGoogle Scholar
  91. 91.
    Kyle UG, Genton L, Pichard C. Body composition: what’s new? Curr Opin Clin Nutr Metab Care. 2002;5(4): 427–433PubMedGoogle Scholar
  92. 92.
    Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. Arch Intern Med. 2002; 162(18): 2074–2079PubMedGoogle Scholar
  93. 93.
    Visser M, Langlois J, Guralnik JM, Cauley JA, Kronmal RA, Robbins J, Williamson JD, Harris TB. High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr. 1998; 68(3): 584–590PubMedGoogle Scholar
  94. 94.
    Baumgartner RN, Wayne SJ, Waters DL, Janssen I, Gallagher D, Morley JE. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res. 2004; 12(12): 1995–2004PubMedGoogle Scholar
  95. 95.
    Houston DK, Stevens J, Cai J. Abdominal fat distribution and functional limitations and disability in a biracial cohort: the Atherosclerosis Risk in Communities Study. Int J Obes (Lond). 2005;29(12): 1457–1463Google Scholar
  96. 96.
    Villareal DT, Banks M, Sinacore DR, Siener C, Klein S. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med. 2006; 166(8): 860–866PubMedGoogle Scholar
  97. 97.
    Ensrud KE, Ewing SK, Stone KL, et al. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc. 2003;51(12): 1740–1747PubMedGoogle Scholar
  98. 98.
    Newman AB, Yanez D, Harris T, et al. Weight change in old age and its association with mortality. J Am Geriatr Soc. 2001;49(10): 1309–1318PubMedGoogle Scholar
  99. 99.
    Cederholm T, Jägrén C, Hellström K. Outcome of protein-energy malnutrition in elderly medical patients. Am J Med. 1995;98(1): 67–74PubMedGoogle Scholar
  100. 100.
    Roubenoff R, Heymsfield SB, Kehayias JJ, Cannon JG, Rosenberg IH. Standardization of nomenclature of body composition in weight loss. Am J Clin Nutr. 1997;66(1): 192–196PubMedGoogle Scholar
  101. 101.
    Thomas DR. Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr. 2007;26(4): 389–399PubMedGoogle Scholar
  102. 102.
    Fearon KC, Von Meyenfeldt MF, Moses AG, et al. Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut. 2003;52(10): 1479–1486PubMedGoogle Scholar
  103. 103.
    Freund-Levi Y, Eriksdorter-Jönhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. ArchNeurol. 2006;63(10): 1402–1408Google Scholar
  104. 104.
    Fiatarone MA, O’Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330(25): 1769–1775PubMedGoogle Scholar
  105. 105.
    Berenstein EG, Ortiz Z. Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005;(2):CD004310Google Scholar
  106. 106.
    Evans WJ. Editorial: Megestrol acetate use for weight gain should be carefully considered. J Clin Endocrinol Metab. 2007;92(2): 420–421PubMedGoogle Scholar
  107. 107.
    Anker SD, Negassa A, Coats AJ, et al. Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study. Lancet. 2003;361(9363): 1077–1083PubMedGoogle Scholar
  108. 108.
    Andersson P, Cederholm T, Johansson AS, Palmblad J. Captopril-impaired production of tumor necrosis factor-alpha-induced interleukin-1beta in human monocytes is associated with altered intracellular distribution of nuclear factorkappaB. J Lab Clin Med. 2002; 140(2): 103–109PubMedGoogle Scholar
  109. 109.
    Cesari M, Leeuwenburgh C, Lauretani F, et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr. 2006;83(5): 1142–1148PubMedGoogle Scholar

Copyright information

© Springer-Verlag France and Serdi Éditions 2008

Authors and Affiliations

  • G. Abellan van Kan
    • 1
  • G. Gambassi
    • 2
  • L. C. P. G. M. de Groot
    • 3
  • S. Andrieu
    • 1
    • 4
    • 5
  • T. Cederholm
    • 6
  • E. Andre
    • 7
  • J. -R. Caudere
    • 8
  • J. -R. Bonjour
    • 9
  • P. Ritz
    • 10
  • A. Salva
    • 11
  • A. Sinclair
    • 12
  • B. Vellas
    • 1
    • 5
  1. 1.Department of Geriatric Medicine, Pavillon J.P. JunodCHU ToulouseToulouse cedex 9France
  2. 2.Università Cattolica del Sacro CuoreRomeItaly
  3. 3.Division of Human NutritionWageningen UniversityWageningenThe Netherlands
  4. 4.Department of Epidemiology and Public HealthUniversity IIIFrance
  5. 5.Inserm U-558University Toulouse IIIFrance
  6. 6.Uppsala UniversityUppsalaSweden
  7. 7.Public HealthGrenobleFrance
  8. 8.Pierre Fabre LabsCastresFrance
  9. 9.University Hospitals and Faculty of MedicineGenevaSwitzerland
  10. 10.University of AngersAngersFrance
  11. 11.Institut Català de l’EnvellimentUniversitat Autónoma de BarcelonaSpain
  12. 12.University of BedfordshireLutonUK

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