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Urinary excretion of fluorescent advanced glycation end products (AGEs) in the elderly

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The Journal of Nutrition Health and Aging

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References

  1. Schleicher ED, Wagner E, Nerlich. Increased accumulation of the glycoxidation product Ne-(carboxymethyl)lysine in human tissues in diabetes and ageing. J Clin Invest 1999; 99: 457–468.

    Article  Google Scholar 

  2. Chen J, Takahashi M, Suzuki M, Kushida K, Miyamoto S, Inoue S. Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis. Reumatology 1999; 38: 1275–1278.

    Article  CAS  Google Scholar 

  3. Vlitek P, Bhattacharya K; Glendening JM; Stopa E; Vlassara H; Bucala R; Manogue K, Cerami A: Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci 1994;91: 4766–4770.

    Article  Google Scholar 

  4. Vlassara H, Brownlee M, Cerami A. Nonenzymatic glycosylation: role in the pathogenesis of diabetic complications. Clin Chem 1986; 32: 37–41.

    Google Scholar 

  5. Zilin S, Naifeng L, Bicheng L, Jiping W. The determination of AGE-peptides by flow injection assay, a practical marker of diabetic nephropathy. Clin Chim Acta 2001;313: 69–75.

    Article  PubMed  CAS  Google Scholar 

  6. Goldberg T, Cai W, Peppa M, Dardaine V, Suresh B, Uribarril J, Vlassara H. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004; 104: 1287–1291.

    Article  PubMed  CAS  Google Scholar 

  7. Cai W, Gao QD, Zhu L, Peppa M, He C, Vlassara H. Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction. Mol Med.2002;8: 337–46.

    PubMed  CAS  Google Scholar 

  8. Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield EJ. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002; 26;99: 15596–601.

    Article  CAS  Google Scholar 

  9. Peppa M, Uribarri J, Cai W, Lu M, Vlassara H. Glycoxidation and inflammation in renal failure patients. Am J Kidney Dis. 2004;43: 690–5.

    Article  PubMed  CAS  Google Scholar 

  10. Brownlee M. Negative consequences of glycation. Metabolism 2000;49, suppl 1: 9–3.

    Article  PubMed  CAS  Google Scholar 

  11. Bonnefont-Rousselot D. Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care. 2002;5: 561–8.

    Article  PubMed  CAS  Google Scholar 

  12. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function — measured and estimated glomerular filtration rate. N Engl J Med 2006; 354: 2473–83.

    Article  PubMed  CAS  Google Scholar 

  13. Brownlee M, Vlassara H, Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med. 1984;101: 527–37.

    PubMed  CAS  Google Scholar 

  14. Kalousova M, Sulkova S, Zima T, Deppisch R, Beck W, Bednarova V, Fortova M, Tesar V. Advanced glycation end products in hemodialyzed patients with diabetes mellitus correlate with leptin and leptin/body fat ratio. Ren Fail. 2003;25: 277–86.

    Article  PubMed  CAS  Google Scholar 

  15. O’Brien J. Nutricional and toxicological aspects of the Maillard browning reaction in foods. Crit Rev Food Sci Nutr 1989;28: 211–248.

    Article  PubMed  CAS  Google Scholar 

  16. Peppa M, Uribarri J, Cai W, Lu M, Vlassara H. Glycoxidation and inflammation in renal failure patients. Am J Kidney Dis. 2004; 43: 690–5.

    Article  PubMed  CAS  Google Scholar 

  17. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci. 1997;94: 6474–9.

    Article  PubMed  CAS  Google Scholar 

  18. Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005;1043: 461–6.

    Article  PubMed  CAS  Google Scholar 

  19. Roberts MA, Thomas MC, Fernando D, MacMillan N, Power DA, Ierino FL. Low molecular weight advanced glycation end products predict mortality in asymptomatic patients receiving chronic haemodialysis. Nephrol Dial Transplant 2006; EPUB ahead of print

  20. Atalah E, Benavides X, Avila L, Barahona S, Cárdenas R. Dietary characteristics Nutritional features of elders living in poor communities of the Metropolitan Region of Chile. Rev. Med. Chile 1998;126: 489–496.

    PubMed  CAS  Google Scholar 

  21. Sjoholm A, Nystrom T. Endothelial inflammation in insulin resistance. Lancet. 2005;365: 610–2

    PubMed  Google Scholar 

  22. Odetti P, Rossi S, Monacelli F, Poggi A, Cirnigliaro M, Federici M, Federici A. Advanced glycation end products and bone loss during aging. Ann N Y Acad Sci. 2005;1043: 710–7.

    Article  PubMed  CAS  Google Scholar 

  23. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Curr Opin Pharmacol. 2004;4: 301–5.

    Article  PubMed  CAS  Google Scholar 

  24. Hein G, Weiss C, Lehmann G, Niwa T, Stein G, Franke S. Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings. Ann Rheum Dis. 2006 65: 101–4.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to M. P. de la Maza.

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Financing: FONDECyT Grant 1030597.

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de la Maza, M.P., Bravo, A., Leiva, L. et al. Urinary excretion of fluorescent advanced glycation end products (AGEs) in the elderly. J Nutr Health Aging 12, 222–224 (2008). https://doi.org/10.1007/BF02982625

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  • DOI: https://doi.org/10.1007/BF02982625

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