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Archives of Pharmacal Research

, 30:1155 | Cite as

Effects of vehicles and enhancers on transdermal delivery of clebopride

  • Yun-Seok Rhee
  • Jai-Yong Huh
  • Chun-Woong Park
  • Tae-Young Nam
  • Koog-Ryul Yoon
  • Sang-Cheol Chi
  • Eun-Seok Park
Article Drug development

Abstract

The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 μg/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.

Key words

Clebopride Skin permeation Vehicle Enhancer Binary vehicle system 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Yun-Seok Rhee
    • 1
  • Jai-Yong Huh
    • 1
  • Chun-Woong Park
    • 1
  • Tae-Young Nam
    • 1
  • Koog-Ryul Yoon
    • 1
  • Sang-Cheol Chi
    • 1
  • Eun-Seok Park
    • 1
  1. 1.College of PharmacySungkyunkwan UniversitySuwonKorea

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