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Archives of Pharmacal Research

, Volume 30, Issue 9, pp 1062–1066 | Cite as

A phenylpropanoid glycoside with antioxidant activity from picria tel-ferae

  • Nguyen Duy Thuan
  • Do Thi Ha
  • Phuong Thien Thuong
  • Min Kyun Na
  • KiHwan Bae
  • Jong Pill Lee
  • Jeong-Hun Lee
  • Hyo-Won Seo
  • Byung-Sun Min
  • Jin-Cheol Kim
Article Drug discovery

Abstract

A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)-ethyl-β-D-apiofuranosyl-(1→4)-α-L-rharmnopyranosyl-(1→3)-4-O-caffeoyl-β-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2′-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical (Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.

Key words

Picria tel-ferae Scrophulariaceae Phenylpropanoid glycoside Antioxidant Lipid peroxidation 

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Copyright information

© The Pharmaceutical Society of Korea 2007

Authors and Affiliations

  • Nguyen Duy Thuan
    • 1
  • Do Thi Ha
    • 1
    • 2
  • Phuong Thien Thuong
    • 2
  • Min Kyun Na
    • 2
  • KiHwan Bae
    • 2
  • Jong Pill Lee
    • 3
  • Jeong-Hun Lee
    • 4
  • Hyo-Won Seo
    • 4
  • Byung-Sun Min
    • 4
  • Jin-Cheol Kim
    • 5
  1. 1.National Institute of Medicinal MaterialsHanoiVietnam
  2. 2.College of PharmacyChungnam National UniversityDaejeonKorea
  3. 3.Korea Food and Drug AdministrationSeoulKorea
  4. 4.College of PharmacyCatholic University of DaeguGyeongbukKorea
  5. 5.Korea Research Institute of Chemical TechnologyDaejeonKorea

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