Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica
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In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex ofMelia azedarach var.japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds1 and2 showed marked inhibitory activity of iNOS on LPS-and interferon-γ-stimulated RAW 264.7 cells.
Key wordsMelia azedarach var.japonica 4-Methoxy-1-vinyl-carboline 4,8-Dimethoxy-1-vinyl-β-carboline Inducible nitric oxide synthase
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