Advertisement

Archives of Pharmacal Research

, Volume 22, Issue 4, pp 410–413 | Cite as

Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica

  • Hak Cheol Kwon
  • Byeong Gon Lee
  • Seung Hee Kim
  • Chil Mann Jung
  • Sung Youl Hong
  • Jeung Whan Han
  • Hyang Woo Lee
  • Ok Pyo Zee
  • Kang Ro Lee
Research Articles Natural products

Abstract

In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex ofMelia azedarach var.japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds1 and2 showed marked inhibitory activity of iNOS on LPS-and interferon-γ-stimulated RAW 264.7 cells.

Key words

Melia azedarach var.japonica 4-Methoxy-1-vinyl-carboline 4,8-Dimethoxy-1-vinyl-β-carboline Inducible nitric oxide synthase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References Cited

  1. Ahn, J. W., Choi, S. U. and Lee, C. O., Cytotoxic limonoids fromMelia azedarach var.japonica.Phytochemistry 36(6), 1493–1496, 1994.CrossRefGoogle Scholar
  2. Amin, A. R., Attur, M. G., Thakker, G. D. and Abramson, S. B., A novel mechanism of action of tetracyclines: Effects on nitric oxide synthase.Proc. Natl. Acad. Sci, 93, 14014–14019, 1996.PubMedCrossRefGoogle Scholar
  3. Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., Tannenbaum, S. R., Analysis of nitrate, nitrite, and [15N]-nitrate in biological fluids.Analyt. Biochem, 126, 131–138, 1982.PubMedCrossRefGoogle Scholar
  4. Hayashi, T., Abe, E., Yamate, T., Taguchi, Y. and Jasin, H. E., Nitric oxide production by superficial and deep articular chondrocytes.Arthritis & Rheumatism, 40, (2), 261–269, 1997.CrossRefGoogle Scholar
  5. Ohmoto, T. and Koike, K., Studies on the constituents ofPicrasma quassioides Bennet. I. On the Alkaloidal Constituents.Chem. Pharm. Bull., 30 (4), 1204–1209, 1982.Google Scholar
  6. Ohmoto, T. and Koike, K., Studies on the constituents ofPicrasma quassioides Bennet. II. On the Alkaloidal Constituents.Chem. Pharm. Bull., 31 (9), 3198–3204, 1983.Google Scholar
  7. Shanghai Science and Technologic Publisher and Shougakukan in: The Dictionary of Chinese Drugs. Shougakukan, Tokyo, p. 602 (1985).Google Scholar
  8. Srivastava, S. D., Limonoids from the seeds ofMelia azedarach.J. Nat. Prod. 9 (1), 56–61, 1986.CrossRefGoogle Scholar
  9. Takeya, K., Qiao, Z. S., Hirobe, C. and Itokawa, H., Cytotoxic azadirachtin-type limonoids fromMelia azedarach.Phytochemistry, 42 (3), 709–712, 1996a.PubMedCrossRefGoogle Scholar
  10. Takeya, K., Qiao, Z. S., Hirobe, C. and Itokawa, H., Cytotoxic trichilin-type limonoids fromMelia azedarach.Bioorganic & Medicinal Chemistry, 4 (8), 1355–1359, 1996b.CrossRefGoogle Scholar
  11. Vodovotz, Y., Bogdan, C., Paik, J., Xie, Q. W., and Nathan, C., Mechanisms of suppression of macrophage nitrix oxide release by transforming growth factor.J. Exp. Med., 178, 605–613, 1993.PubMedCrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Hak Cheol Kwon
    • 3
  • Byeong Gon Lee
    • 3
  • Seung Hee Kim
    • 1
  • Chil Mann Jung
    • 3
  • Sung Youl Hong
    • 2
  • Jeung Whan Han
    • 3
  • Hyang Woo Lee
    • 3
  • Ok Pyo Zee
    • 3
  • Kang Ro Lee
    • 3
  1. 1.National Institute of Toxicological ResearchKorea Food and Drug AdministrationSeoulKorea
  2. 2.College of Life Science and Natural ResourcesSung Kyun Kwan UniversitySuwonKorea
  3. 3.Natural Product Laboratory, College of PharmacySung Kyun Kwan UniversitySuwonKorea

Personalised recommendations