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Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica

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Abstract

In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids, 4-methoxy-1-vinyl-β-carboline (1) and 4,8-dimethoxy-1-vinyl-β-carboline (2) have been isolated from the cortex ofMelia azedarach var.japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds1 and2 showed marked inhibitory activity of iNOS on LPS-and interferon-γ-stimulated RAW 264.7 cells.

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Authors and Affiliations

  1. National Institute of Toxicological Research, Korea Food and Drug Administration, 122-020, Seoul, Korea

    Seung Hee Kim

  2. College of Life Science and Natural Resources, Sung Kyun Kwan University, 440-746, Suwon, Korea

    Sung Youl Hong

  3. Natural Product Laboratory, College of Pharmacy, Sung Kyun Kwan University, Chonchon-dong 300, Jangan-ku, 440-746, Suwon, Korea

    Hak Cheol Kwon, Byeong Gon Lee, Chil Mann Jung, Jeung Whan Han, Hyang Woo Lee, Ok Pyo Zee & Kang Ro Lee

Authors
  1. Hak Cheol Kwon
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  2. Byeong Gon Lee
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  3. Seung Hee Kim
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  4. Chil Mann Jung
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  5. Sung Youl Hong
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  7. Hyang Woo Lee
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  9. Kang Ro Lee
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Correspondence to Kang Ro Lee.

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Kwon, H.C., Lee, B.G., Kim, S.H. et al. Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica . Arch Pharm Res 22, 410–413 (1999). https://doi.org/10.1007/BF02979067

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  • DOI: https://doi.org/10.1007/BF02979067

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