Isocoumarin derivatives from the sea squirt-derived fungus penicillium stoloniferum QY2-10 and the halotolerant fungus penicillium notatum B-52
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Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5a, 8a-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3 β-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus,Penicillium stoloniferum QY2-10, and a halophilic fungus,Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 μ.M.
Key wordsSea squirt-derived fungus Penicillium stoloniferum Halotolerant fungus Penicillium notatum Stoloniferol A and B
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- Brown, J. P., Robertson, A., Whalley, W. B., and Cartwright, N. J., Chemistry of fungi. V. The constitution of citrinin.J. Chem. Soc, 867 879 (1949).Google Scholar
- Hassall, C. H. and Jones, D. W., The biosynthesis of phenols. IV. A new metabolic product ofAspergillus terreus.J. Chem. Soc, 4189–4191 (1962).Google Scholar
- Yaoita, Y, Amemiya, K., Ohnuma, H., Furumura, K., Masaki, A., Matsuki, T., and Kikuchi, M., Sterol constituents from five edible mushrooms.Chem. Pharm. Bull., 46, 944–950 (1998).Google Scholar