Cytotoxic constituents ofPsoralea corylifolia

Research Article Pharmacology, Toxicology & Pharmaceutics


A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds ofPsoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 μg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates1–3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

Key words

Psoralea corylifolia Psoralidin Angelicin Psoralen Cytotoxicity 


  1. Baskin, J. M., Ludlow, C. J., Harris, T. M., and Wolf, F. T. Psoralen, an inhibitor in the seeds ofPsoralea subacaulis.Phytochemistry, 6, 1209–1213 (1967).CrossRefGoogle Scholar
  2. Bensky, D. and Gamble, A. Chinese herbal medicine: Materia Medica. Revised edition. Eastland Press, Seattle, Washington, pp. 344–345 (1993).Google Scholar
  3. Inocenti, G., Cappelletti, E. M., and Caporale, G. Furocoumarin contents in the vegetative organs of cultivated Psoralea species.Int. J. Pharmacog., 29, 311–316 (1991).CrossRefGoogle Scholar
  4. Kondo, Y., Kato, A., Kubota, Y., and Nozoe, S. Bakuchicin, a new simple furanocoumarin fromPsoralea corylifolia.Heterocyles, 31, 187–190 (1990).CrossRefGoogle Scholar
  5. Mehta, G., Naysak, U. R., and Dev, S. Monoterpenoids. I.Psoralea corylifolia Linn. 1. bakuchiol, a novel monoterpene phenol.Tetrahedron 29, 1119–1125 (1973).CrossRefGoogle Scholar
  6. Miura, H., Nishida, H., and Iinuma, M. Effect of crude fractions ofPsoralea corylifolia seed extract on bone calcification.Planta Med. 62, 150–153 (1996).PubMedCrossRefGoogle Scholar
  7. Ryu, S. Y., Choi, S.U., Lee, C. C., and Zee, O. P. Antitumor activity ofPsoralea corylifolia.Arch. Pharm. Res., 15, 356–359 (1992).CrossRefGoogle Scholar
  8. Tsai, W. J., Hsin, W. C., and Chen, C. C. Antiplatelet flavonoids from seeds ofPsoralea corylifolia.J. Nat. Prod., 59, 671–672 (1996).PubMedCrossRefGoogle Scholar
  9. Yang, Y. -M., Hyun, J. -W., Sung, M. -S., Chung, H. -S., Kim, B. -K., Paik, W.-H., Kang, S. -S., and Park, J.-G. The cytotoxicity of Psoralidin fromPsoralea corylifolia.Planta Med., 62, 353–354 (1996).PubMedCrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2001

Authors and Affiliations

  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea
  2. 2.Natural Products Chemistry Laboratory, College of PharmacyEwha Womans UniversitySeoulKorea

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