Cytotoxic constituents ofPsoralea corylifolia
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds ofPsoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 μg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates1–3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.
Key wordsPsoralea corylifolia Psoralidin Angelicin Psoralen Cytotoxicity
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