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Synthesis of new salicylamide derivatives with evaluation of their antiinflammatory, analgesic and antipyretic activities

  • H. H. Fahmy
  • G. A. Soliman
Research Article Medicinal Chemistry & Natural Products

Abstract

A new series of pyridazine, pyrazoles, pyrazolidine-3,5-dione, Semicarbazide, thiosemicarbazides, hydantoin, thiohydantoins, 1,2,4-triazoles, S-triazolo[3,4-b]-1,3,4-thiadiazoles incorporated indirectly into salicylamide moiety at position 2 were synthesized. Also the synthesis of novel series of 3-salicylamido-2-hydroxypropyl-amine derivatives were prepared. Several of these compounds were screened for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.

Key words

Salicylamide derivatives 1,2,4-Triazoles S-Triazolo[3,4-b]-1,3,4-thiadiazoles pyrazoles Antiinflammatory analgesic and antipyretic activities 

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Copyright information

© The Pharmaceutical Society of Korea 2001

Authors and Affiliations

  1. 1.Therapeutical Chemistry DepartmentNational Research CentreDokki, CairoEgypt
  2. 2.Faculty Vet. Med., Dept. of PharmacologyCairo UniversityEgypt

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