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Archives of Pharmacal Research

, Volume 17, Issue 1, pp 17–20 | Cite as

Synthesis of 2-(2-fluorenyl)propanoic acid

  • Hong Dae Choi
  • Dek Hyun Geum
  • Yong Sil Kowak
  • Byeng Wha Son
Article

Abstract

Friedel-Crafts reaction of fluorene with methyl α-chloro-α-(methylthio)acetate1 gave methyl α-methylthio-2-fluoreneacetate2. Cicloprofen8, a potent antiinflammatory agent, was prepared by methylation of2 followed by reductive desulfurization of methyl 2-(2-fluorenyl)-2-(methylthio)propionate6 and hydrolysis of methyl 2-(2-fluorenyl)propionate7.

Key words

Friedel-Crafts reaction Fluorene Methyl α-chloro-α-(methylthio)acetate Cicloprofen Antiinflammatory agent Methylation Reductive desulfurization Hydrolysis 

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References Cited

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Copyright information

© The Pharmaceutical Society of Korea 1994

Authors and Affiliations

  • Hong Dae Choi
    • 1
  • Dek Hyun Geum
    • 1
  • Yong Sil Kowak
    • 1
  • Byeng Wha Son
    • 2
  1. 1.Department of ChemistryDongeui UniversityPusanKorea
  2. 2.Department of ChemistryNational Fisheries University of PusanPusanKorea

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